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J R Soc Med. 1989 December; 82(12): 747–752.
PMCID: PMC1292422

Tell me about free radicals, doctor: a review.

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Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.1M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Halliwell B. Oxidants and human disease: some new concepts. FASEB J. 1987 Nov;1(5):358–364. [PubMed]
  • Scott G. Potential toxicological problems associated with antioxidants in plastics and rubber consumables. Free Radic Res Commun. 1988;5(3):141–147. [PubMed]
  • Breimer LH. Ionizing radiation-induced mutagenesis. Br J Cancer. 1988 Jan;57(1):6–18. [PMC free article] [PubMed]
  • Curnutte JT, Babior BM. Chronic granulomatous disease. Adv Hum Genet. 1987;16:229–297. [PubMed]
  • Kettle AJ, Winterbourn CC. Superoxide modulates the activity of myeloperoxidase and optimizes the production of hypochlorous acid. Biochem J. 1988 Jun 1;252(2):529–536. [PubMed]
  • Gryglewski RJ, Palmer RM, Moncada S. Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor. Nature. 1986 Apr 3;320(6061):454–456. [PubMed]
  • Halliwell B. Superoxide, iron, vascular endothelium and reperfusion injury. Free Radic Res Commun. 1989;5(6):315–318. [PubMed]
  • Farr SB, D'Ari R, Touati D. Oxygen-dependent mutagenesis in Escherichia coli lacking superoxide dismutase. Proc Natl Acad Sci U S A. 1986 Nov;83(21):8268–8272. [PubMed]
  • Levander OA. A global view of human selenium nutrition. Annu Rev Nutr. 1987;7:227–250. [PubMed]
  • Halliwell B, Gutteridge JM. The importance of free radicals and catalytic metal ions in human diseases. Mol Aspects Med. 1985;8(2):89–193. [PubMed]
  • Halliwell B. Lipid peroxidation in vivo and in vitro in relation to atherosclerosis: some fundamental questions. Agents Actions Suppl. 1988;26:223–231. [PubMed]
  • McLaren GD, Muir WA, Kellermeyer RW. Iron overload disorders: natural history, pathogenesis, diagnosis, and therapy. Crit Rev Clin Lab Sci. 1983;19(3):205–266. [PubMed]
  • Aruoma OI, Bomford A, Polson RJ, Halliwell B. Nontransferrin-bound iron in plasma from hemochromatosis patients: effect of phlebotomy therapy. Blood. 1988 Oct;72(4):1416–1419. [PubMed]
  • Halliwell B, Gutteridge JM. Oxygen free radicals and iron in relation to biology and medicine: some problems and concepts. Arch Biochem Biophys. 1986 May 1;246(2):501–514. [PubMed]
  • Esterbauer H, Striegl G, Puhl H, Rotheneder M. Continuous monitoring of in vitro oxidation of human low density lipoprotein. Free Radic Res Commun. 1989;6(1):67–75. [PubMed]
  • Gey KF, Brubacher GB, Stähelin HB. Plasma levels of antioxidant vitamins in relation to ischemic heart disease and cancer. Am J Clin Nutr. 1987 May;45(5 Suppl):1368–1377. [PubMed]
  • Carew TE, Schwenke DC, Steinberg D. Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit. Proc Natl Acad Sci U S A. 1987 Nov;84(21):7725–7729. [PubMed]
  • Marcillat O, Zhang Y, Lin SW, Davies KJ. Mitochondria contain a proteolytic system which can recognize and degrade oxidatively-denatured proteins. Biochem J. 1988 Sep 15;254(3):677–683. [PubMed]
  • Muller DP, Lloyd JK, Wolff OH. Vitamin E and neurological function. Lancet. 1983 Jan 29;1(8318):225–228. [PubMed]
  • Kretzer FL, Mehta RS, Johnson AT, Hunter DG, Brown ES, Hittner HM. Vitamin E protects against retinopathy of prematurity through action on spindle cells. Nature. 309(5971):793–795. [PubMed]
  • Halliwell B, Hoult JR, Blake DR. Oxidants, inflammation, and anti-inflammatory drugs. FASEB J. 1988 Oct;2(13):2867–2873. [PubMed]
  • Baldwin SR, Simon RH, Grum CM, Ketai LH, Boxer LA, Devall LJ. Oxidant activity in expired breath of patients with adult respiratory distress syndrome. Lancet. 1986 Jan 4;1(8471):11–14. [PubMed]
  • Bolli R. Oxygen-derived free radicals and postischemic myocardial dysfunction ("stunned myocardium"). J Am Coll Cardiol. 1988 Jul;12(1):239–249. [PubMed]
  • Gower J, Healing G, Green C. Measurement by HPLC of desferrioxamine-available iron in rabbit kidneys to assess the effect of ischaemia on the distribution of iron within the total pool. Free Radic Res Commun. 1989;5(4-5):291–299. [PubMed]
  • Halliwell B, Aruoma OI, Mufti G, Bomford A. Bleomycin-detectable iron in serum from leukaemic patients before and after chemotherapy. Therapeutic implications for treatment with oxidant-generating drugs. FEBS Lett. 1988 Dec 5;241(1-2):202–204. [PubMed]
  • Hall ED, Yonkers PA. Attenuation of postischemic cerebral hypoperfusion by the 21-aminosteroid U74006F. Stroke. 1988 Mar;19(3):340–344. [PubMed]
  • Hall ED. Effects of the 21-aminosteroid U74006F on posttraumatic spinal cord ischemia in cats. J Neurosurg. 1988 Mar;68(3):462–465. [PubMed]
  • Hall ED, Yonkers PA, McCall JM, Braughler JM. Effects of the 21-aminosteroid U74006F on experimental head injury in mice. J Neurosurg. 1988 Mar;68(3):456–461. [PubMed]
  • Halliwell B, Gutteridge JM. Lipid peroxidation, oxygen radicals, cell damage, and antioxidant therapy. Lancet. 1984 Jun 23;1(8391):1396–1397. [PubMed]

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