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J R Soc Med. 1989 December; 82(12): 712–716.
PMCID: PMC1292411

Postviral syndrome--how can a diagnosis be made? A study of patients undergoing a Monospot test.


Eighty-nine of 150 patients having a Monospot test filled out a questionnaire about their illness, and the General Health Questionnaire. They completed a follow-up questionnaire 6 months later. Twelve (8%) had a positive Monospot. Twenty-eight of 83 serum samples tested (34%) were positive for VP1 enteroviral antigen. Forty of the patients had a self limiting illness, 13 had a definite diagnosis (excepting glandular fever), 14 had a possible postviral syndrome, 10 had recurrent sore throats/flu, and 12 had a chronic non-specific illness. Patients with a specific diagnosis were less likely to complain of aching muscles/joints, sore throat, tiredness or loss of concentration. Their GHQ scores were lower, although this just failed to reach significance (P = 0.08), and they scored significantly lower on the somatic symptoms subscale (P = 0.022). Overall 72% scored above the GHQ threshold for 'psychological caseness' which is higher than in other studies. Sixty-five per cent of the sample questioned at 6 months felt that their illness started with a viral infection. The methodological problems involved in making a diagnosis of postviral syndrome are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Dawson J. Royal Free disease: perplexity continues. Br Med J (Clin Res Ed) 1987 Feb 7;294(6568):327–328. [PMC free article] [PubMed]
  • Wagner BM. Left ventricular hypertrophy and sudden death. Hum Pathol. 1986 Jan;17(1):1–1. [PubMed]
  • Calder BD, Warnock PJ. Coxsackie B infection in a Scottish general practice. J R Coll Gen Pract. 1984 Jan;34(258):15–19. [PMC free article] [PubMed]
  • Yousef GE, Bell EJ, Mann GF, Murugesan V, Smith DG, McCartney RA, Mowbray JF. Chronic enterovirus infection in patients with postviral fatigue syndrome. Lancet. 1988 Jan 23;1(8578):146–150. [PubMed]
  • Goldberg D. Use of the general health questionnaire in clinical work. Br Med J (Clin Res Ed) 1986 Nov 8;293(6556):1188–1189. [PMC free article] [PubMed]
  • David AS, Wessely S, Pelosi AJ. Postviral fatigue syndrome: time for a new approach. Br Med J (Clin Res Ed) 1988 Mar 5;296(6623):696–699. [PMC free article] [PubMed]

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