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J R Soc Med. 1989 October; 82(10): 598–599.
PMCID: PMC1292334

Placental angiogenic and growth factors in the treatment of chronic varicose ulcers: preliminary communication.


A short-term clinical study on the effect of purified angiogenic and growth factors from human term placenta in the treatment of chronic varicose ulcers was carried out in 18 patients. Patients were randomly allocated to receive a maximum of two dressings containing or not containing these factors. The amount of granulation and epithelial tissue was clinically estimated 48 hours after each application. Patients treated with placental angiogenic and growth factors showed increased granulation and epithelial tissue. These results indicate that placental factors may be used for acceleration of wound healing.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Bennett JP, Matthews R, Faulk WP. Treatment of chronic ulceration of the legs with human amnion. Lancet. 1980 May 31;1(8179):1153–1156. [PubMed]
  • Faulk WP, Matthews R, Stevens PJ, Bennett JP, Burgos H, Hsi BL. Human amnion as an adjunct in wound healing. Lancet. 1980 May 31;1(8179):1156–1158. [PubMed]
  • Burgos H. Angiogenic and growth factors in human amnio-chorion and placenta. Eur J Clin Invest. 1983 Aug;13(4):289–296. [PubMed]
  • Burgos H. Angiogenic factor from human term placenta. Purification and partial characterization. Eur J Clin Invest. 1986 Dec;16(6):486–493. [PubMed]

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