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J R Soc Med. 1989 October; 82(10): 595–597.
PMCID: PMC1292333

Use of auditory evoked responses as a measure of recovery from benzodiazepine sedation.


The amplitude of the P300 component of auditory evoked responses was found to be depressed by benzodiazepine sedation and was subsequently used to monitor the recovery of volunteers sedated with midazolam. The amplitude of the evoked responses was found to be highly correlated with blood midazolam levels but to be no more sensitive than standard psychomotor testing in assessing recovery from sedation.

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Selected References

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  • Thornton C, Catley DM, Jordan C, Lehane JR, Royston D, Jones JG. Enflurane anaesthesia causes graded changes in the brainstem and early cortical auditory evoked response in man. Br J Anaesth. 1983 Jun;55(6):479–486. [PubMed]
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  • Hedner T, Persson B, Berglund G. Ketanserin, a novel 5-hydroxytryptamine antagonist: monotherapy in essential hypertension. Br J Clin Pharmacol. 1983 Aug;16(2):121–125. [PMC free article] [PubMed]
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