Search tips
Search criteria 


Logo of jrsocmedLink to Publisher's site
J R Soc Med. 1989 August; 82(8): 466–469.
PMCID: PMC1292251

Gross and histological criteria for developmental disorders in brains of schizophrenics.


Autopsy findings and examination of histological sections from 12 schizophrenic patients and from age-matched, non-schizophrenic controls were enlarged and confirmed our previous study. Four subgroups were differentiated with gross abnormalities, in most cases with asymmetry of the temporal sulcal gyral pattern. Two types of macroscopical deviations are described. Different periods of developmental termination, concerning the sulcal gyral pattern of the temporal lobe, suggest a period in which the disturbance of the development originated which coincides with a probably genetically-induced disturbed migration in the entorhinal region toward the end of the fifth month. It is thought that the parahippocampal or entorhinal area develops differently, space- and time-wise. This may explain why migratory disturbances particularly occur in this precisely limited area. The findings in the ventral insular area are discussed, together with factors which also suggest a developmental disorder.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.3M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Bogerts B, Meertz E, Schönfeldt-Bausch R. Basal ganglia and limbic system pathology in schizophrenia. A morphometric study of brain volume and shrinkage. Arch Gen Psychiatry. 1985 Aug;42(8):784–791. [PubMed]
  • Brown R, Colter N, Corsellis JA, Crow TJ, Frith CD, Jagoe R, Johnstone EC, Marsh L. Postmortem evidence of structural brain changes in schizophrenia. Differences in brain weight, temporal horn area, and parahippocampal gyrus compared with affective disorder. Arch Gen Psychiatry. 1986 Jan;43(1):36–42. [PubMed]
  • Jakob H, Beckmann H. Prenatal developmental disturbances in the limbic allocortex in schizophrenics. J Neural Transm. 1986;65(3-4):303–326. [PubMed]
  • Kovelman JA, Scheibel AB. A neurohistological correlate of schizophrenia. Biol Psychiatry. 1984 Dec;19(12):1601–1621. [PubMed]
  • Stevens JR, Casanova MF. Is there a neuropathology of schizophrenia? Biol Psychiatry. 1988 Jun;24(2):123–128. [PubMed]
  • Nowakowski RS, Rakic P. The site of origin and route and rate of migration of neurons to the hippocampal region of the rhesus monkey. J Comp Neurol. 1981 Feb 10;196(1):129–154. [PubMed]
  • Rakic P, Nowakowski RS. The time of origin of neurons in the hippocampal region of the rhesus monkey. J Comp Neurol. 1981 Feb 10;196(1):99–128. [PubMed]
  • Rakic P. Mode of cell migration to the superficial layers of fetal monkey neocortex. J Comp Neurol. 1972 May;145(1):61–83. [PubMed]
  • Rakic P. Neuronal migration and contact guidance in the primate telencephalon. Postgrad Med J. 1978;54 (Suppl 1):25–40. [PubMed]
  • Schmechel DE, Rakic P. Arrested proliferation of radial glial cells during midgestation in rhesus monkey. Nature. 1979 Jan 25;277(5694):303–305. [PubMed]
  • Fernández V. An autoradiographic study of the development of the anterior thalamic group and limbic cortex in the rabbit. J Comp Neurol. 1969 Aug;136(4):423–452. [PubMed]
  • Shimada M, Abe Y, Yamano T, Ohta S, Yamazaki S, Ohya N. The pathogenesis of abnormal cytoarchitecture in the cerebral cortex and hippocampus of the mouse treated transplacentally with cytosine arabinoside. Acta Neuropathol. 1982;58(3):159–167. [PubMed]
  • Segal M, Landis S. Afferents to the hippocampus of the rat studied with the method of retrograde transport of horseradish peroxidase. Brain Res. 1974 Sep 20;78(1):1–15. [PubMed]
  • Hjorth-Simonsen A. Projection of the lateral part of the entorhinal area to the hippocampus and fascia dentata. J Comp Neurol. 1972 Oct;146(2):219–232. [PubMed]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press