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J R Soc Med. 1989 August; 82(8): 462–463.
PMCID: PMC1292249

Lymphopenia in rheumatoid arthritis.

Abstract

Lymphopenia is a recognized but poorly studied feature of rheumatoid arthritis (RA). We set out to establish the prevalence and significance of lymphopenia in RA. A group of 66 RA patients was studied for one year. During this time 10 (15%) had persistent lymphopenia (lymphocyte count less than 1.00 X 10(9)/l) without evidence of Felty's syndrome. A separate study of lymphocyte subsets in 13 lymphopenic RA patients showed marked reduction in T-cell numbers with normal circulating B-cell numbers. The numbers of CD4 and CD8 positive T-cells were equally depressed. Lymphopenia may indicate more severe disease. It was not influenced by changes in disease activity or therapy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
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Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press