Search tips
Search criteria 


Logo of jrsocmedLink to Publisher's site
J R Soc Med. 1989 June; 82(6): 345–346.
PMCID: PMC1292166

Tissue oxygenation, venous ulcers and fibrin cuffs.


Skin oxygen tension (TcPO2) was measured at 43 degrees C on patients (n = 27) with venous ulcers. Measurements were made at ulcer edge and proximally on the same limb for control. Similar measurements were also made on healthy volunteers (n = 14) in the medial aspects of the distal third of the legs. TcPO2 at ulcer edge was significantly lower (P = 0.001) than control values which in turn were lower than that measured on healthy volunteers. TcPO2 reflects skin nutrition. While low TcPO2 at ulcer edges might be the result of pericapillary barriers to oxygen transport, the control values measured on apparently normal skin suggest the need for further studies.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (376K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Browse NL, Burnand KG. The cause of venous ulceration. Lancet. 1982 Jul 31;2(8292):243–245. [PubMed]
  • Falanga V, Moosa HH, Nemeth AJ, Alstadt SP, Eaglstein WH. Dermal pericapillary fibrin in venous disease and venous ulceration. Arch Dermatol. 1987 May;123(5):620–623. [PubMed]
  • Mani R, Gorman FW, White JE. Transcutaneous measurements of oxygen tension at edges of leg ulcers: preliminary communication. J R Soc Med. 1986 Nov;79(11):650–654. [PMC free article] [PubMed]
  • Sindrup JH, Avnstorp C, Steenfos HH, Kristensen JK. Transcutaneous PO2 and laser Doppler blood flow measurements in 40 patients with venous leg ulcers. Acta Derm Venereol. 1987;67(2):160–163. [PubMed]
  • Huch A, Huch R, Rooth G. Monitoring the intravascular Po2 in newborn infants. J Perinat Med. 1973;1(1):53–59. [PubMed]
  • Dowd GS, Linge K, Bentley G. Measurement of transcutaneous oxygen pressure in normal and ischaemic skin. J Bone Joint Surg Br. 1983 Jan;65(1):79–83. [PubMed]
  • Matsen FA, 3rd, Wyss CR, Pedegana LR, Krugmire RB, Jr, Simmons CW, King RV, Burgess EM. Transcutaneous oxygen tension measurement in peripheral vascular disease. Surg Gynecol Obstet. 1980 Apr;150(4):525–528. [PubMed]
  • Clyne CA, Ramsden WH, Chant AD, Webster JH. Oxygen tension on the skin of the gaiter area of limbs with venous disease. Br J Surg. 1985 Aug;72(8):644–647. [PubMed]
  • Thomas PR, Nash GB, Dormandy JA. White cell accumulation in dependent legs of patients with venous hypertension: a possible mechanism for trophic changes in the skin. Br Med J (Clin Res Ed) 1988 Jun 18;296(6638):1693–1695. [PMC free article] [PubMed]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press