Search tips
Search criteria 


Logo of jrsocmedLink to Publisher's site
J R Soc Med. 1989; 82(Suppl 17): 14–17.
PMCID: PMC1291931

Changing pattern of antimalarial drug resistance.


With the current increase of international travel and increasing drug resistance, United Kingdom residents stand a high risk of contracting malaria when they visit endemic countries. The development of anti-malarial agents from old traditional plant remedies to modern synthetic drugs is briefly reviewed. Resistance to the latter has spread rapidly since the 1950s, culminating in the widespread distribution of multiple drug-resistant strains of Plasmodium falciparum in most endemic areas. There is a danger that such parasites may rapidly develop resistance even to new compounds such as mefloquine, halofantrine or artemisinin unless the use of such compounds is carefully controlled. The few developments, including new drugs and ways of reversing existing resistance, are also briefly reviewed in this paper. Emphasis is laid on the need to revert to classical methods of protection against malaria vectors since it is unlikely that a protective vaccine will become available in the near future.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (781K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Klayman DL. Qinghaosu (artemisinin): an antimalarial drug from China. Science. 1985 May 31;228(4703):1049–1055. [PubMed]
  • Kilimali VA, Mkufya AR, Kilama WL. Low resistance of Plasmodium falciparum to mefloquine in Tanga region, Tanzania. Trans R Soc Trop Med Hyg. 1989 Mar-Apr;83(2):162–164. [PubMed]
  • Peters W, Robinson BL, Ellis DS. The chemotherapy of rodent malaria. XLII. Halofantrine and halofantrine resistance. Ann Trop Med Parasitol. 1987 Oct;81(5):639–646. [PubMed]
  • Chawira AN, Warhurst DC, Peters W. Qinghaosu resistance in rodent malaria. Trans R Soc Trop Med Hyg. 1986;80(3):477–480. [PubMed]
  • Martin SK, Oduola AM, Milhous WK. Reversal of chloroquine resistance in Plasmodium falciparum by verapamil. Science. 1987 Feb 20;235(4791):899–901. [PubMed]
  • Foote SJ, Thompson JK, Cowman AF, Kemp DJ. Amplification of the multidrug resistance gene in some chloroquine-resistant isolates of P. falciparum. Cell. 1989 Jun 16;57(6):921–930. [PubMed]
  • Chatterjee VK, Lee JK, Rentoumis A, Jameson JL. Negative regulation of the thyroid-stimulating hormone alpha gene by thyroid hormone: receptor interaction adjacent to the TATA box. Proc Natl Acad Sci U S A. 1989 Dec;86(23):9114–9118. [PubMed]
  • Miller LH, Good MF. The main obstacle to a malaria vaccine: the malaria parasite. Vaccine. 1988 Apr;6(2):104–106. [PubMed]
  • Peters W. How to prevent malaria. Trop Doct. 1987 Jan;17(1):1–3. [PubMed]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press