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J R Soc Med. 1988 November; 81(11): 633–636.
PMCID: PMC1291839

Modulating the oxygen tension in tumours by hypothermia and hyperbaric oxygen.


Hypothermia is associated with reduced metabolism of tissues and especially reduced oxygen consumption by tumours. If the blood supply to a hypothermic tumour can be maintained then the hypoxic fraction of cells should be reduced and the radiation response increased. This hypothesis has been tested with radiation under hyperbaric oxygen and increased tumour response has been demonstrated.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • THOMLINSON RH, GRAY LH. The histological structure of some human lung cancers and the possible implications for radiotherapy. Br J Cancer. 1955 Dec;9(4):539–549. [PMC free article] [PubMed]
  • Dische S, Anderson PJ, Sealy R, Watson ER. Carcinoma of the cervix--anaemia, radiotherapy and hyperbaric oxygen. Br J Radiol. 1983 Apr;56(664):251–255. [PubMed]
  • Nias AH, Perry P, Photiou A, Reghebi K. Effect of hypothermia on radiosensitization. Int J Radiat Biol Relat Stud Phys Chem Med. 1986 Aug;50(2):241–251. [PubMed]
  • Tozer GM, Penhaligon M, Nias AH. The use of ketamine plus diazepam anaesthesia to increase the radiosensitivity of a C3H mouse mammary adenocarcinoma in hyperbaric oxygen. Br J Radiol. 1984 Jan;57(673):75–80. [PubMed]
  • SAPIRSTEIN LA. Regional blood flow by fractional distribution of indicators. Am J Physiol. 1958 Apr;193(1):161–168. [PubMed]
  • Chan RC, Babbs CF, Vetter RJ, Lamar CH. Abnormal response of tumor vasculature to vasoactive drugs. J Natl Cancer Inst. 1984 Jan;72(1):145–150. [PubMed]
  • Sealy R, Harrison GG, Morrell D, Korrubel J, Gregory A, Barry L, Blekkenhorst G, Hering ER, Fataar AB, Boniaszczuk J. A feasibility study of a new approach to clinical radiosensitisation: hypothermia and hyperbaric oxygen in combination with pharmacological vasodilatation. Br J Radiol. 1986 Nov;59(707):1093–1098. [PubMed]

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