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J R Soc Med. 1988 October; 81(10): 576–578.
PMCID: PMC1291800

The ocular signs and complications of epidermolysis bullosa.


Eleven patients with the dystrophic form of epidermolysis bullosa underwent ophthalmic assessment to establish the presence, characteristics, and extent of any ocular involvement. Eight patients were found to have eye changes: these included varying degrees of symblepharon, broadening of the limbus, and corneal opacities. Taken as a group, these changes formed a characteristic pattern. The majority of patients were asymptomatic and the ocular changes appear to be only slowly progressive. Recurrent corneal abrasion and symblepharon are the most important complications.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Granek H, Baden HP. Corneal involvement in epidermolysis bullosa simplex. Arch Ophthalmol. 1980 Mar;98(3):469–472. [PubMed]
  • Aurora AL, Madhavan M, Rao S. Ocular changes in epidermolysis bullosa letalis. Am J Ophthalmol. 1975 Mar;79(3):464–470. [PubMed]
  • SORSBY A, FRASER ROBERTS JA, BRAIN RT. Essential shrinking of the conjunctiva in a hereditary affection allied to epidermolysis bullosa. Doc Ophthalmol. 1951;5-6:118–150. [PubMed]
  • FORGACS J, FRANCESCHETTI A. Histologic aspect of corneal changes; due to hereditary, metabolic, and cutaneous affections. Am J Ophthalmol. 1959 May;47(5 Pt 2):191–202. [PubMed]
  • Wright P. Cicatrizing conjunctivitis. Trans Ophthalmol Soc U K. 1986;105(Pt 1):1–17. [PubMed]
  • Johnson L, Eisenberg M. Biochemical defects in epidermolysis bullosa--a review. Australas J Dermatol. 1986 Apr;27(1):11–14. [PubMed]

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