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J R Soc Med. 1988 September; 81(9): 509–513.
PMCID: PMC1291758

Quantitative exfoliative cytology of abnormal oral mucosal smears.


In this study quantitative techniques have been applied to smears collected from the buccal mucosa and floor of the mouth. The results display an encouraging success rate for identifying premalignant and malignant lesions. 'Intrapatient' normal smears provide a satisfactory control for comparison with pathological smears. Early results indicate that quantitative cytology could be of great value for monitoring and follow-up of suspicious lesions and provide an excellent additional diagnostic test for detecting early oral malignancy.

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Selected References

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  • COOKE BE. Exfoliative cytology in evaluating oral lesions. J Dent Res. 1963 Jan-Feb;2:343–347. [PubMed]
  • Shklar G, Meyer I, Cataldo E, Taylor R. Correlated study of oral cytology and histopathology. Report on 2,052 oral lesions. Oral Surg Oral Med Oral Pathol. 1968 Jan;25(1):61–70. [PubMed]
  • Folsom TC, White CP, Bromer L, Canby HF, Garrington GE. Oral exfoliative study. Review of the literature and report of a three-year study. Oral Surg Oral Med Oral Pathol. 1972 Jan;33(1):61–74. [PubMed]
  • Allegra SR, Broderick PA, Corvese N. Oral cytology. Seven year oral cytology screening program in the State of Rhode Island. Analysis of 6448 cases. Acta Cytol. 1973 Jan-Feb;17(1):42–48. [PubMed]
  • Williams RG. The early diagnosis of carcinoma of the mouth. Ann R Coll Surg Engl. 1981 Nov;63(6):423–425. [PMC free article] [PubMed]
  • Mincer HH, Coleman SA, Hopkins KP. Observations on the clinical characteristics of oral lesions showing histologic epithelial dysplasia. Oral Surg Oral Med Oral Pathol. 1972 Mar;33(3):389–399. [PubMed]
  • Franklin CD, Smith CJ. Stereological analysis of histological parameters in experimental premalignant hamster cheek pouch epithelium. J Pathol. 1980 Mar;130(3):201–215. [PubMed]
  • Kramer IR, Lucas RB, el-Labban N, Lister L. A computer-aided study on the tissue changes in oral keratoses and lichen planus, and an analysis of case groupings by subjective and objective criteria. Br J Cancer. 1970 Sep;24(3):407–426. [PMC free article] [PubMed]
  • Kramer IR, Lucas RB, el-Labban N, Lister L. The use of discriminant analysis for examining the histological feathers of oral keratoses and lichen planus. Br J Cancer. 1970 Dec;24(4):673–683. [PMC free article] [PubMed]
  • SANDLER HC, STAHL SS, CAHN LR, FREUND HR. Exfoliative cytology for detection of early mouth cancer. Oral Surg Oral Med Oral Pathol. 1960 Aug;13:994–1009. [PubMed]
  • SELBACH GJ, VONHAAM E. THE CLINICAL VALUE OF ORAL CYTOLOGY. Acta Cytol. 1963 Nov-Dec;7:337–345. [PubMed]
  • Bernstein ML, Miller RL. Oral exfoliative cytology. J Am Dent Assoc. 1978 Apr;96(4):625–629. [PubMed]
  • Meyer-Arendt JR, Humphreys DM. Quantitative morphology of cancer cells. Acta Histochem. 1972;44(1):41–48. [PubMed]
  • Hayes RL, Berg GW, Ross WL. Oral cytology: its value and its limitations. J Am Dent Assoc. 1969 Sep;79(3):649–657. [PubMed]
  • Shklar G, Cataldo E, Meyer I. Reliability of cytologic smear in diagnosis of oral cancer. A controlled study. Arch Otolaryngol. 1970 Feb;91(2):158–160. [PubMed]
  • Cowpe JG, Longmore RB. Nuclear area and Feulgen DNA content of normal buccal mucosal smears. J Oral Pathol. 1981 Apr;10(2):81–86. [PubMed]
  • Doyle JL, Manhold JH., Jr Feulgen microspectrophotometry of oral cancer and leukoplakia. J Dent Res. 1975 Nov-Dec;54(6):1196–1199. [PubMed]
  • Sprenger E, Witte S. The diagnostic significance of nuclear deoxyribonucleic acid measurement in automated cytology. J Histochem Cytochem. 1979 Jan;27(1):520–521. [PubMed]
  • Pfitzer P, Pape HD. Investigation of DNA-content of leukoplakia cells or oral mucosa. J Maxillofac Surg. 1975 Jun;3(2):119–124. [PubMed]
  • Cowpe JG, Longmore RB, Green MW. Quantitative exfoliative cytology of normal oral squames: an age, site and sex-related survey. J R Soc Med. 1985 Dec;78(12):995–1004. [PMC free article] [PubMed]
  • Cowpe JG. Quantitative exfoliative cytology of normal and abnormal oral mucosal squames: preliminary communication. J R Soc Med. 1984 Nov;77(11):928–931. [PMC free article] [PubMed]
  • Watanabe Y. Methods for the early diagnosis of oral tumors. Oral cytology. Int Dent J. 1968 Dec;18(4):708–723. [PubMed]
  • UMIKER WO, LAMPE I, RAPP R, HINIKER JJ. Oral smears in the diagnosis of carcinoma and premalignant lesions. Oral Surg Oral Med Oral Pathol. 1960 Aug;13:897–907. [PubMed]
  • PETERS H. Cytologic smears from the mouth; cellular changes in disease and after radiation. Am J Clin Pathol. 1958 Mar;29(3):219–225. [PubMed]
  • King OH, Jr, Coleman SA. Analysis of oral exfoliative cytologic accuracy by control biopsy technique. Acta Cytol. 1965 Sep-Oct;9(5):351–354. [PubMed]
  • Silverman S., Jr Observations on the clinical characteristics and natural history of oral leukoplakia. J Am Dent Assoc. 1968 Apr;76(4):772–777. [PubMed]
  • Dumbach J, Sitzmann F, Pesch HJ. Diagnostisches Vorgehen bei Verdacht auf Malignom der Mundhöhle unter besonderer berücksichtigung der Exfoliativ-Zytologie. Dtsch Zahnarztl Z. 1981 Nov;36(11):697–700. [PubMed]
  • NIEBURGS HE, HERMAN BE, REISMAN H. Buccal cell changes in patients with malignant tumors. Lab Invest. 1962 Jan;2:80–88. [PubMed]
  • Finch RR. A classification of nuclear aberration in relation to malignancy associated changes (MAC). Acta Cytol. 1971 Nov-Dec;15(6):553–558. [PubMed]
  • Bánóczy J, Rigó O. Comparative cytologic and histologic studies in oral leukoplakia. Acta Cytol. 1976 Jul-Aug;20(4):308–312. [PubMed]
  • Schwarz K, Böcking A, Lehmann W, Hahn W. Möglichkeiten und Grenzen der Exfoliativzytologie zur Beurteilung der Dignität von Mundschleimhautveränderungen. Dtsch Zahnarztl Z. 1981 Nov;36(11):701–703. [PubMed]
  • Silverman Sol, Bilimoria KF, Bhargava K, Mani NJ, Shah RA. Cytologic, histologic and clinical correlations of precancerous and cancerous oral lesions in 57,518 industrial workers of Gujarat, India. Acta Cytol. 1977 Mar-Apr;21(2):196–198. [PubMed]
  • Sandler HC. Errors of oral cytodiagnosis report of follow-up of 1,801 patients. J Am Dent Assoc. 1966 Apr;72(4):851–854. [PubMed]
  • Poswillo D. Evaluation, surveillance and treatment of panoral leukoplakia. J Maxillofac Surg. 1975 Dec;3(4):205–211. [PubMed]

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