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J R Soc Med. 1988 March; 81(3): 158–160.
PMCID: PMC1291511

Why not have definitive trials of gastrointestinal safety for non-steroidal anti-inflammatory drugs? Discussion paper.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Kurata JH, Elashoff JD, Grossman MI. Inadequacy of the literature on the relationship between drugs, ulcers, and gastrointestinal bleeding. Gastroenterology. 1982 Feb;82(2):373–376. [PubMed]
  • Elashoff JD, Grossman MI. Trends in hospital admissions and death rates for peptic ulcer in the United States from 1970 to 1978. Gastroenterology. 1980 Feb;78(2):280–285. [PubMed]
  • Allan R, Dykes P. A study of the factors influencing mortality rates from gastrointestinal haemorrhage. Q J Med. 1976 Oct;45(180):533–550. [PubMed]
  • Cohen MM. Treatment and mortality of perforated peptic ulcer: a survey of 852 cases. Can Med Assoc J. 1971 Aug 7;105(3):263–passim. [PMC free article] [PubMed]
  • Lanza FL, Royer GL, Jr, Nelson RS, Chen TT, Seckman CE, Rack MF. The effects of ibuprofen, indomethacin, aspirin, naproxen, and placebo on the gastric mucosa of normal volunteers: a gastroscopic and photographic study. Dig Dis Sci. 1979 Nov;24(11):823–828. [PubMed]
  • Lanza FL, Umbenhauer ER, Nelson RS, Rack MF, Daurio CP, White LA. A double-blind randomized placebo controlled gastroscopic study to compare the effects of indomethacin capsules and indomethacin suppositories on the gastric mucosa of human volunteers. J Rheumatol. 1982 May-Jun;9(3):415–419. [PubMed]
  • Vakil BJ, Shah PN, Dalal NJ, Wagholikar UN, Pispati PK. Endoscopic study of gastro-intestinal injury with non-steroidal anti-inflammatory drugs. Curr Med Res Opin. 1977;5(1):38–42. [PubMed]
  • Pemberton RE, Strand LJ. A review of upper-gastrointestinal effects of the newer nonsteroidal antiinflammatory agents. Dig Dis Sci. 1979 Jan;24(1):53–64. [PubMed]
  • Stephens FO, Lawrenson KB. 51Cr Excretion in bile. Lancet. 1969 Jan 18;1(7586):158–159. [PubMed]
  • Slater TF, Delaney VB. Liver adenosine triphosphate content and bile flow rate in the rat. Biochem J. 1970 Jan;116(2):303–308. [PubMed]
  • Levy M. Aspirin use in patients with major upper gastrointestinal bleeding and peptic-ulcer disease. A report from the Boston Collaborative Drug Surveillance Program, Boston University Medical Center. N Engl J Med. 1974 May 23;290(21):1158–1162. [PubMed]
  • Trewby PN. Drug-induced peptic ulcer and upper gastrointestinal bleeding. Br J Hosp Med. 1980 Feb;23(2):185–190. [PubMed]
  • Clinch D, Banerjee AK, Levy DW, Ostick G, Faragher EB. Non-steroidal anti-inflammatory drugs and peptic ulceration. J R Coll Physicians Lond. 1987 Jul;21(3):183–187. [PubMed]
  • Collier DS, Pain JA. Non-steroidal anti-inflammatory drugs and peptic ulcer perforation. Gut. 1985 Apr;26(4):359–363. [PMC free article] [PubMed]
  • HILL AB. THE ENVIRONMENT AND DISEASE: ASSOCIATION OR CAUSATION? Proc R Soc Med. 1965 May;58:295–300. [PMC free article] [PubMed]
  • Jick H, Vessey MP. Case-control studies in the evaluation of drug-induced illness. Am J Epidemiol. 1978 Jan;107(1):1–7. [PubMed]
  • Clinch D, Banerjee AK, Ostick G. Absence of abdominal pain in elderly patients with peptic ulcer. Age Ageing. 1984 Mar;13(2):120–123. [PubMed]
  • KERN F, Jr, CLARK GM, LUKENS JG. Peptic ulceration occurring during therapy for rheumatoid arthritis. Gastroenterology. 1957 Jul;33(1):25–33. [PubMed]
  • Bonnevie O. The incidence of gastric ulcer in Copenhagen county. Scand J Gastroenterol. 1975;10(3):231–239. [PubMed]

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