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J R Soc Med. 1988 January; 81(1): 13–14.
PMCID: PMC1291419

Simplifying infusion chemotherapy: preliminary communication.


A low-intervention policy for Hickman catheter maintenance has been evaluated and found to be safe and cost effective. A simple, lightweight, disposable device has been used for 24-hour ambulatory home infusion. Implementation of this policy as part of a prospective randomized trial of single-agent chemotherapy in advanced breast cancer has demonstrated that slow intravenous infusion reduces the acute toxicity of epirubicin when compared with bolus injection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Jones WG, Mattsson W. Phase II study of weekly low-dose 4'-epi-doxorubicin in advanced postmenopausal breast cancer. Cancer Treat Rep. 1984 Apr;68(4):675–677. [PubMed]
  • Jain KK, Casper ES, Geller NL, Hakes TB, Kaufman RJ, Currie V, Schwartz W, Cassidy C, Petroni GR, Young CW, et al. A prospective randomized comparison of epirubicin and doxorubicin in patients with advanced breast cancer. J Clin Oncol. 1985 Jun;3(6):818–826. [PubMed]
  • Carlson RW, Sikic BI. Continuous infusion or bolus injection in cancer chemotherapy. Ann Intern Med. 1983 Dec;99(6):823–833. [PubMed]

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