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J R Soc Med. 1987 November; 80(11): 694–695.
PMCID: PMC1291091

Phenylephrine-induced reversible cataract in the mouse.


Topical 10% phenylephrine will produce lens opacities in several strains of mouse. These lens opacities resolve spontaneously within 24 hours, leaving an apparently normal eye. Phenylephrine-induced lens opacification in the mouse can be prevented by covering the eye with ointment, suggesting that the underlying mechanism is transcorneal dehydration.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • FRAUNFELDER FT, BURNS RP. Production of unilateral reversible cataracts in the hamster. Proc Soc Exp Biol Med. 1962 May;110:72–74. [PubMed]
  • Fraunfelder FT, Burns RP. Effect of lid closure in drug-induced experimental cataracts. Arch Ophthalmol. 1966 Oct;76(4):599–601. [PubMed]
  • Auricchio G, Libondi T. The physiologic and pharmacologic factors protecting the lens transparency and the update approach to the prevention of experimental cataracts: a review. Metab Pediatr Syst Ophthalmol. 1983;7(2):115–124. [PubMed]
  • Fraunfelder FT, Burns RP. Acute reversible lens opacity: caused by drugs, cold, anoxia, asphyxia, stress, death and dehydration. Exp Eye Res. 1970 Jul;10(1):19–30. [PubMed]

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