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J R Soc Med. 1987 August; 80(8): 484–485.
PMCID: PMC1290952

Why is plasma angiotensin-converting enzyme activity elevated in hyperthyroidism?


The elevation in plasma angiotensin-converting enzyme (ACE) levels observed in patients with hyperthyroidism is unexplained. In this study three hypotheses were investigated. Results from a study using rats treated with thyroid hormones indicated that the increased ACE was not due to increased cleavages of enzyme from lung endothelia. Data from patients with specific tissue damage argue against a nonspecific release of ACE from damaged cells. Data from cultured cell experiments, however, strongly support a direct effect of thyroid hormones upon ACE synthesis and secretion.

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Selected References

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  • Yotsumoto H, Imai Y, Kuzuya N, Uchimura H, Matsuzaki F. Increased levels of serum angiotensin-converting enzyme activity in hyperthyroidism. Ann Intern Med. 1982 Mar;96(3):326–328. [PubMed]
  • Nakamura Y, Takeda T, Ishii M, Nishiyama K, Yamakada M, Hirata Y, Kimura K, Murao S. Elevation of serum angiotensin-converting enzyme activity in patients with hyperthyroidism. J Clin Endocrinol Metab. 1982 Nov;55(5):931–934. [PubMed]
  • Smallridge RC, Rogers J, Verma PS. Serum angiotensin-converting enzyme. Alterations in hyperthyroidism, hypothyroidism, and subacute thyroiditis. JAMA. 1983 Nov 11;250(18):2489–2493. [PubMed]
  • Czernobilsky H, Fiehn W, Ziegler R. Comparison of serum angiotensin-converting enzyme in Graves' disease, toxic nodular goiter, and other thyroid conditions. Klin Wochenschr. 1985 Jun 3;63(11):518–522. [PubMed]
  • Ashkar FS, Miller R, Smoak WM, 3rd, Gilson AJ. Liver disease in hyperthyroidism. South Med J. 1971 Apr;64(4):462–465. [PubMed]
  • Beckett GJ, Kellett HA, Gow SM, Hussey AJ, Hayes JD, Toft AD. Raised plasma glutathione S-transferase values in hyperthyroidism and in hypothyroid patients receiving thyroxine replacement: evidence for hepatic damage. Br Med J (Clin Res Ed) 1985 Aug 17;291(6493):427–431. [PMC free article] [PubMed]
  • Maguire GA, Price CP. A continuous monitoring spectrophotometric method for the measurement of angiotensin-converting enzyme in human serum. Ann Clin Biochem. 1985 Mar;22(Pt 2):204–210. [PubMed]

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