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J R Soc Med. 1987 August; 80(8): 475–476.
PMCID: PMC1290947

Polycythaemia following renal transplantation.

Abstract

Polycythaemia has developed in 10 of 59 regularly reviewed patients with renal transplants surviving more than three months. The pathology of the raised haemoglobin level was heterogeneous. Three patients had a picture characterized by a normal red cell mass and reduced plasma volume. Seven patients had a raised red cell mass; in 3 of these this was associated with a period of abnormal liver function and fitted with the state of raised red cell mass in association with hepatic transaminitis. The remaining 4 patients form a unique, previously undefined group with no features to explain the underlying aetiology of the polycythaemia. The patients had a trouble-free post-transplant course with early establishment of graft function. It is proposed, from the data obtained from in vitro culture studies, that the early return of good renal function allows the erythroid compartment to expand in response to circulating erythropoietin. The establishment of an erythron of increased size allows for a persistently raised haemoglobin in the presence of normal erythropoietin levels.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Napier JA, Evans J. Erythropoietin assay using fetal mouse liver cell cultures: a modified technique using semi-automatic harvesting of I125 deoxyuridine labelled erythroblasts. Clin Lab Haematol. 1980;2(1):13–19. [PubMed]
  • Zanjani ED, Lutton JD, Hoffman R, Wasserman LR. Erythroid colony formation by polycythemia vera bone marrow in vitro. Dependence on erythropoietin. J Clin Invest. 1977 May;59(5):841–848. [PMC free article] [PubMed]
  • Prchal JF, Adamson JW, Murphy S, Steinmann L, Fialkow PJ. Polycythemia vera. The in vitro response of normal and abnormal stem cell lines to erythropoietin. J Clin Invest. 1978 Apr;61(4):1044–1047. [PMC free article] [PubMed]
  • Simon P, Meyrier A, Tanquerel T, Ang KS. Improvement of anaemia in haemodialysed patients after viral or toxic hepatic cytolysis. Br Med J. 1980 Mar 29;280(6218):892–894. [PMC free article] [PubMed]
  • Coleman JC, Eastwood JB, Curtis JR, Fox RA, Edwards MS. Hepatitis and epidemic hepatitis associated antigen (E.H.A.A.) in a haemodialysis unit with observations on haemoglobin levels. Br J Urol. 1972 Apr;44(2):194–201. [PubMed]
  • Dagher FJ, Ramos E, Erslev AJ, Alongi SV, Karmi SA, Caro J. Are the native kidneys responsible for erythrocytosis in renal allorecipients? Transplantation. 1979 Dec;28(6):496–498. [PubMed]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press