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J R Soc Med. 1987 April; 80(4): 207–209.
PMCID: PMC1290759

Effects of cytotoxic chemotherapy on dental development.


A histological study of 21 teeth from 9 patients who had received cytotoxic chemotherapy for malignant disease showed increased prominence of incremental lines in the dentine. The number and distribution of these lines corresponded to periods of intravenous therapy and vincristine appeared to be the most likely cause. This effect was probably due to temporary disturbance of microtubular function in the odontoblasts resulting in decreased secretion of collagenous dentine matrix. Calcification appeared to be unaffected.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Levine RS, Turner EP, Dobbing J. Deciduous teeth contain histories of developmental disturbances. Early Hum Dev. 1979 Jul;3(2):211–220. [PubMed]
  • Welbury RR, Craft AW, Murray JJ, Kernahan J. Dental health of survivors of malignant disease. Arch Dis Child. 1984 Dec;59(12):1186–1187. [PMC free article] [PubMed]
  • Adatia AK. Response of the dental elements to chemotherapy of Burkitt's tumour. Int Dent J. 1968 Sep;18(3):646–654. [PubMed]
  • Ehrlich HP, Ross R, Bornstein P. Effects of antimicrotubular agents on the secretion of collagen. A biochemical and morphological study. J Cell Biol. 1974 Aug;62(2):390–405. [PMC free article] [PubMed]
  • Moskalewski S, Thyberg J, Lohmander S, Friberg U. Influence of colchicine and vinblastine on the golgi complex and matrix deposition in chondrocyte aggregates. An ultrastructural study. Exp Cell Res. 1975 Oct 15;95(2):440–454. [PubMed]
  • Stene T, Koppang HS. The effect of vincristine on dentinogenesis in the rat incisor. Scand J Dent Res. 1976 Sep;84(5):342–344. [PubMed]
  • Stene T, Koppang HS. Autoradiographic investigation of dentin production in rat incisors after vincristine administration. Scand J Dent Res. 1980 Apr;88(2):104–112. [PubMed]

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