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J R Soc Med. 1986 October; 79(10): 584–587.
PMCID: PMC1290497

Does dimethicone increase the efficacy of antacids in the treatment of reflux oesophagitis?

Abstract

Dimethicone is a common additive to antacids, although its value in the treatment of reflux oesophagitis is unproven. Its efficacy was assessed by comparing the effect of a dimethicone-containing antacid gel (Asilone Gel) with a simple antacid gel in a double-blind trial in 45 patients with reflux oesophagitis. Thirty-eight patients completed the eight-week course of therapy. Antacid therapy alone resulted in a significant improvement of both symptoms and oesophagitis in gastro-oesophageal reflux. The inclusion of dimethicone in the antacid gel preparation did not confer any benefit in terms of symptomatic assessment but did confer a small advantage with regard to objective markers of oesophageal inflammation, suggesting that a dimethicone-containing antacid is of value in the treatment of symptomatic gastro-oesophageal reflux.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Bernstein JE, Kasich AM. A double-blind trial of simethicone in functional disease of the upper gastrointestinal tract. J Clin Pharmacol. 1974 Nov-Dec;14(11-12):617–623. [PubMed]
  • Bernstein JE, Schwartz SR. An evaluation of the effectiveness of simethicone in acute upper gastrointesinal distress. Curr Ther Res Clin Exp. 1974 Jun;16(6):617–620. [PubMed]
  • Birtley RD, Burton JS, Kellett DN, Oswald BJ, Pennington JC. The effect of free silica on the mucosal protective and antiflatulent properties of polydimethylsiloxane. J Pharm Pharmacol. 1973 Nov;25(11):859–863. [PubMed]
  • James SL, Marriott C. An investigation of the effect of an antacid mucosal protective on gastric mucus. Pharm Acta Helv. 1982;57(9):265–267. [PubMed]
  • Sixsmith D, McCluskey D. The effect of punch tip geometry on powder movement during the tableting process. J Pharm Pharmacol. 1981 Feb;33(2):79–81. [PubMed]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press