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J R Soc Med. 1986 August; 79(8): 462–464.
PMCID: PMC1290417

Carcinoma of the colon--association with low dietary vitamin A in females: preliminary communication.

Abstract

Seventeen patients with non-metastatic carcinoma of the colon (9 male, 8 female) were compared with age- and sex-matched controls in a study examining the relationship of diet and altered cholesterol metabolism with carcinoma of the colon. Bile acid excretion in the faeces was significantly less in cancer patients (P less than 0.001), and a significantly lower intake of retinol (P less than 0.01) and vitamin A (P less than 0.05) was demonstrated in female cancer patients. There was no difference between patients and controls in hepatic cholesterol enzyme activity or in fasting plasma lipid levels.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Habba SF, Daly L, Doyle JS. Epidemiology of carcinoma of the colon and rectum in Ireland: mortality analysis. Ir J Med Sci. 1982 Jan;151(1):6–11. [PubMed]
  • Cruse P, Lewin M, Clark CG. Dietary cholesterol is co-carcinogenic for human colon cancer. Lancet. 1979 Apr 7;1(8119):752–755. [PubMed]
  • Broitman SA. Cholesterol excretion and colon cancer. Cancer Res. 1981 Sep;41(9 Pt 2):3738–3740. [PubMed]
  • Jain M, Cook GM, Davis FG, Grace MG, Howe GR, Miller AB. A case-control study of diet and colo-rectal cancer. Int J Cancer. 1980 Dec 15;26(6):757–768. [PubMed]
  • Burkitt DP, Walker AR, Painter NS. Effect of dietary fibre on stools and the transit-times, and its role in the causation of disease. Lancet. 1972 Dec 30;2(7792):1408–1412. [PubMed]
  • Reddy BS, Hedges A, Laakso K, Wynder EL. Fecal constituents of a high-risk North American and a low-risk Finnish population for the development of large bowel cancer. Cancer Lett. 1978 Apr;4(4):217–222. [PubMed]
  • Willett WC, Polk BF, Underwood BA, Stampfer MJ, Pressel S, Rosner B, Taylor JO, Schneider K, Hames CG. Relation of serum vitamins A and E and carotenoids to the risk of cancer. N Engl J Med. 1984 Feb 16;310(7):430–434. [PubMed]
  • Garland C, Shekelle RB, Barrett-Connor E, Criqui MH, Rossof AH, Paul O. Dietary vitamin D and calcium and risk of colorectal cancer: a 19-year prospective study in men. Lancet. 1985 Feb 9;1(8424):307–309. [PubMed]
  • Molloy AM, Tomkin GH. Altered bile in diabetic diarrhoea. Br Med J. 1978 Nov 25;2(6150):1462–1463. [PMC free article] [PubMed]
  • Scott LM, Tomkin GH. Changes in hepatic and intestinal cholesterol regulatory enzymes. The influence of metformin. Biochem Pharmacol. 1983 Mar 1;32(5):827–830. [PubMed]
  • Lea AJ. Dietary factors associated with death-rates from certain neoplasms in man. Lancet. 1966 Aug 6;2(7458):332–333. [PubMed]
  • Wynder EL, Shigematsu T. Environmental factors of cancer of the colon and rectum. Cancer. 1967 Sep;20(9):1520–1561. [PubMed]
  • Armstrong B, Doll R. Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices. Int J Cancer. 1975 Apr 15;15(4):617–631. [PubMed]
  • Murray WR, Backwood A, Trotter JM, Calman KC, MacKay C. Faecal bile acids and clostridia in the aetiology of colorectal cancer. Br J Cancer. 1980 Jun;41(6):923–928. [PMC free article] [PubMed]
  • Mudd DG, McKelvey ST, Norwood W, Elmore DT, Roy AD. Faecal bile acid concentration of patients with carcinoma or increased risk of carcinoma in the large bowel. Gut. 1980 Jul;21(7):587–590. [PMC free article] [PubMed]
  • Sporn MB, Dunlop NM, Newton DL, Smith JM. Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids). Fed Proc. 1976 May 1;35(6):1332–1338. [PubMed]
  • Bollag W. Retinoids and cancer. Cancer Chemother Pharmacol. 1979;3(4):207–215. [PubMed]
  • Kark JD, Smith AH, Switzer BR, Hames CG. Serum vitamin A (retinol) and cancer incidence in Evans County, Georgia. J Natl Cancer Inst. 1981 Jan;66(1):7–16. [PubMed]
  • Wald N, Idle M, Boreham J, Bailey A. Low serum-vitamin-A and subsequent risk of cancer. Preliminary results of a prospective study. Lancet. 1980 Oct 18;2(8199):813–815. [PubMed]

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