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J R Soc Med. 1986 August; 79(8): 460–461.
PMCID: PMC1290416

Trial of (+)-cyanidanol-3 in patients with hepatitis B chronic liver disease.


A double-blind controlled trial of 12 months' treatment with (+)-cyanidanol-3 was carried out in 26 patients with chronic hepatitis B liver disease. Treatment did not improve liver blood tests nor histological appearances of the liver, but there was a trend towards reduction of serum titres of hepatitis B surface antigen.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Schalm SW, Heytink RA, van Buuren HR, de Man RA. Acyclovir enhances the antiviral effect of interferon in chronic hepatitis B. Lancet. 1985 Aug 17;2(8451):358–360. [PubMed]
  • Sagnelli E, Piccinino F, Manzillo G, Felaco FM, Filippini P, Maio G, Pasquale G, Izzo CM. Effect of immunosuppressive therapy on HBsAg-positive chronic active hepatitis in relation to presence or absence of HBeAg and anti-HBe. Hepatology. 1983 Sep-Oct;3(5):690–695. [PubMed]
  • Blum AL, Berthet P, Doelle W, Goebell H, Kortüm K, Pelloni S, Peter P, Poulsen H, Strohmeyer G, Tygstrup N. Treatment of acute viral hepatitis with (+)-cyanidanol-3. Lancet. 1977 Dec 3;2(8049):1153–1155. [PubMed]
  • Schomerus H, Wiedmann KH, Dölle W, Peerenboom H, Strohmeyer G, Balzer K, Goebell H, Dürr HK, Bode C, Blum AL, et al. (+)-Cyanidanol-3 in the treatment of acute viral hepatitis: a randomized controlled trial. Hepatology. 1984 Mar-Apr;4(2):331–335. [PubMed]
  • Pár A, Paál M, Kádas I, Kerekes E, Jávor T. Effect of (+)-cyanidanol-3 (Catergen) in chronic active hepatitis. (Catergen plus prednisolone versus prednisolone in a controlled study). Acta Med Hung. 1983;40(1):17–24. [PubMed]
  • Bar-Meir S, Halpern Z, Gutman M, Shpirer Z, Baratz M, Bass D. Effect of (+)-cyanidanol-3 on chronic active hepatitis: a double blind controlled trial. Gut. 1985 Sep;26(9):975–979. [PMC free article] [PubMed]

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