Search tips
Search criteria 


Logo of jrsocmedLink to Publisher's site
J R Soc Med. 1986 July; 79(7): 391–394.
PMCID: PMC1290375

Cardiovascular risk in patients with treated familial hypercholesterolaemia and patients with severe hypertriglyceridaemia.


A study was performed to determine the morbidity and mortality from ischaemic heart disease (IHD) in patients with heterozygous familial hypercholesterolaemia (FH) and severe hypertriglyceridaemia (pretreatment plasma triglyceride greater than 5 mmol/l). Twenty-nine (38%) of 76 patients with FH and 8(44%) of 18 patients with hypertriglyceridaemia had evidence of IHD. Over a mean follow-up period of 5.5 years, 2 patients with hypertriglyceridaemia died but there were no deaths in patients with FH. This contrasts with earlier reports which showed a high mortality in FH patients. The lower mortality may be due to improved treatment and consequent lower levels of cholesterol.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (703K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Kannel WB, Castelli WP, Gordon T, McNamara PM. Serum cholesterol, lipoproteins, and the risk of coronary heart disease. The Framingham study. Ann Intern Med. 1971 Jan;74(1):1–12. [PubMed]
  • Keys A, Aravanis C, Blackburn H, Van Buchem FS, Buzina R, Djordjevic BS, Fidanza F, Karvonen MJ, Menotti A, Puddu V, et al. Probability of middle-aged men developing coronary heart disease in five years. Circulation. 1972 Apr;45(4):815–828. [PubMed]
  • Hjermann I, Velve Byre K, Holme I, Leren P. Effect of diet and smoking intervention on the incidence of coronary heart disease. Report from the Oslo Study Group of a randomised trial in healthy men. Lancet. 1981 Dec 12;2(8259):1303–1310. [PubMed]
  • Slack J. Risks of ischaemic heart-disease in familial hyperlipoproteinaemic states. Lancet. 1969 Dec 27;2(7635):1380–1382. [PubMed]
  • Onongbu IC, Lewis B. Lipoprotein fractionation by a precipitation method. A simple quantitative procedure. Clin Chim Acta. 1976 Sep 20;71(3):397–402. [PubMed]
  • Burstein M, Scholnick HR, Morfin R. Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions. J Lipid Res. 1970 Nov;11(6):583–595. [PubMed]
  • Jensen J, Blankenhorn DH, Kornerup V. Coronary disease in familial hypercholesterolemia. Circulation. 1967 Jul;36(1):77–82. [PubMed]
  • Heiberg A. The risk of atherosclerotic vascular disease in subjects with xanthomatosis. Acta Med Scand. 1975 Oct;198(4):249–261. [PubMed]
  • McCormick James S, Skrabanek Petr. Familial hypercholesterolaemia. J R Coll Gen Pract. 1985 Feb;35(271):b103–103. [PMC free article]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press