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J R Soc Med. 1986 June; 79(6): 336–338.
PMCID: PMC1290343

How accurate is urine cytology?


Exfoliative urinary cytology was performed on 260 new cases of histologically proven urothelial cancer. The site, size, shape and histological grade of the tumours were documented, and they were classified by the TNM system. Overall, urine cytology was positive in 135 (52%), suspicious in 28 (11%) and negative in 97 (38%) cases. Malignant cells were found most often when the urothelial tumours were large, papillary and solid, moderately or poorly differentiated and invasive (T2-4). Most upper tract tumours and those situated in bladder diverticula had positive urinary cytology. This study confirms that exfoliative urinary cytology is useful in detecting the more malignant bladder tumours including in-situ carcinoma, and other tumours in less accessible parts of the urinary tract.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
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  • HARRISON JH, BOTSFORD TW, TUCKER MR. The use of the smear of the urinary sediment in the diagnosis and management of neoplasm of the kidney and bladder. Surg Gynecol Obstet. 1951 Feb;92(2):129–139. [PubMed]
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  • Esposti PL, Moberger G, Zajicek J. The cytologic diagnosis of transitional cell tumors of the urinary bladder and its histologic basis. A study of 567 cases of urinary-tract disorder including 170 untreated and 182 irradiated bladder tumors. Acta Cytol. 1970 Mar;14(3):145–155. [PubMed]
  • Murphy WM, Soloway MS, Jukkola AF, Crabtree WN, Ford KS. Urinary cytology and bladder cancer. The cellular features of transitional cell neoplasms. Cancer. 1984 Apr 1;53(7):1555–1565. [PubMed]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press