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J R Soc Med. 1985 September; 78(9): 721–724.
PMCID: PMC1289891

Periostitis in secondary syphilis: a place for bone scintigraphy.


Two cases of secondary syphilis are reported with periostitis as the main presenting feature. Technetium-99m bone scintigraphy was found to be superior to radiography in both defining the extent of involvement and in picking up early lesions.

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Selected References

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  • Hansen K, Hvid-Jacobsen K, Lindewald H, Sørensen PS, Weismann K. Bone lesions in early syphilis detected by bone scintigraphy. Br J Vener Dis. 1984 Aug;60(4):265–268. [PMC free article] [PubMed]
  • Roy RB, Laird SM. Acute periostitis in early acquired syphilis. Br J Vener Dis. 1973 Dec;49(6):555–555. [PMC free article] [PubMed]
  • Siegel D, Hirschman SZ. Syphilitic osteomyelitis with diffusely abnormal bone scan. Mt Sinai J Med. 1979 May-Jun;46(3):320–322. [PubMed]
  • Tight RR, Warner JF. Skeletal involvement in secondary syphilis detected by bone scanning. JAMA. 1976 May 24;235(21):2326–2326. [PubMed]

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