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J R Soc Med. 1985 June; 78(6): 459–462.
PMCID: PMC1289775

Effects on upper gastrointestinal mucosa of three delivery systems of potassium as supplement to frusemide administration.

Abstract

Thirty healthy volunteers were recruited into a study to determine the effects on the gastrointestinal mucosa of 3 different delivery systems of oral potassium supplementation associated with diuretic therapy (Diumide-K ContinusR tablets, Napp; Lasikal tablets, Hoechst; Lasix and Slow-KR tablets, Hoechst, Ciba). The volunteers were gastroscoped initially and after one week of treatment with one of the three therapies. There was a 60% incidence of erosions in the Lasix + Slow-K group, a 40% incidence in the Lasikal group, but no erosions in the group receiving Diumide-K Continus tablets. It is therefore concluded that Diumide-K Continus tablets incorporate the potassium in a delivery system which is unlikely to cause disruption to the gastrointestinal mucosa.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Davidson C, McLachlan MS, Burkinshaw L, Morgan DB. Effect of long-term diuretic treatment on body-potassium in heart-disease. Lancet. 1976 Nov 13;2(7994):1044–1047. [PubMed]
  • Dayer P, Cech P, Courvosier B. Chlorure de potassium et ulcères non spécifiques de l'intestin grêle. Schweiz Med Wochenschr. 1977 Mar 19;107(11):379–380. [PubMed]
  • Dyckner T, Helmers C, Lundman T, Wester PO. Initial serum potassium level in relation to early complications and prognosis in patients with acute myocardial infarction. Acta Med Scand. 1975 Mar;197(3):207–210. [PubMed]
  • Farquharson-Roberts MA, Giddings AE, Nunn AJ. Perforation of small bowel due to slow release potassium chloride (slow-K). Br Med J. 1975 Jul 26;3(5977):206–206. [PMC free article] [PubMed]
  • Flear CT. Alterations in water and electrolyte distribution in congestive heart failure and their significance. Ann N Y Acad Sci. 1969 Jan 31;156(1):421–444. [PubMed]
  • Kassirer JP, Harrington JT. Diuretics and potassium metabolism: a reassessment of the need, effectiveness and safety of potassium therapy. Kidney Int. 1977 Jun;11(6):505–515. [PubMed]
  • Lant A. Diuretic therapy. Practitioner. 1977 Oct;219(1312):519–528. [PubMed]
  • LAWRASON FD, ALPERT E, MOHR FL, MCMAHON FG. ULCERATIVE-OBSTRUCTIVE LESIONS OF THE SMALL INTESTINE. JAMA. 1965 Feb 22;191:641–644. [PubMed]
  • Lubbe WF, Cadogan ES, Kannemeyer AH. Oesophageal ulceration due to slow-release potassium in the presence of left atrial enlargement. N Z Med J. 1979 Nov 14;90(647):377–379. [PubMed]
  • McAvoy BR. Letter: Mouth ulceration and slow-release potassium tablets. Br Med J. 1974 Oct 19;4(5937):164–165. [PMC free article] [PubMed]
  • McCall AJ. Letter: Slow-k ulceration of oesophagus with aneurysmal left atrium. Br Med J. 1975 Jul 26;3(5977):230–231. [PMC free article] [PubMed]
  • McLoughlin JC. A study on the effects of a combined frusemide and controlled release potassium tablet (Diumide-K Continus tablets) on gastrointestinal mucosa. Br J Clin Pract. 1984 Mar;38(3):99–101. [PubMed]
  • McMahon FG, Akdamar K. Letter: Gastric ulceration after "slow-K". N Engl J Med. 1976 Sep 23;295(13):733–734. [PubMed]
  • McMahon FG, Ryan JR, Akdamar K, Ertan A. Upper gastrointestinal lesions after potassium chloride supplements: a controlled clinical trial. Lancet. 1982 Nov 13;2(8307):1059–1061. [PubMed]
  • Rao CR. A comparison of the effect of combined frusemide and controlled-release potassium tablets (Diumide-K continus tablets) and frusemide and slow-K tablets in elderly patients with cardiac failure. J Int Med Res. 1982;10(5):357–360. [PubMed]
  • Rosenthal T, Adar R, Militianu J, Deutsch V. Esophageal ulceration and oral potassium chloride ingestion. Chest. 1974 Apr;65(4):463–465. [PubMed]

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