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J R Soc Med. 1985 April; 78(4): 319–327.
PMCID: PMC1289683

Regulation of growth hormone secretion in man: a review.

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Selected References

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  • Ashton IK, Dornan TL, Pocock AE, Turner RC, Bron AJ. Plasma somatomedin activity and diabetic retinopathy. Clin Endocrinol (Oxf) 1983 Jul;19(1):105–110. [PubMed]
  • Beck P, Parker ML, Daughaday WH. Paradoxical hypersecretion of growth hormone in response to glucose. J Clin Endocrinol Metab. 1966 Apr;26(4):463–469. [PubMed]
  • Bloch B, Brazeau P, Ling N, Bohlen P, Esch F, Wehrenberg WB, Benoit R, Bloom F, Guillemin R. Immunohistochemical detection of growth hormone-releasing factor in brain. Nature. 1983 Feb 17;301(5901):607–608. [PubMed]
  • Borges JL, Blizzard RM, Evans WS, Furlanetto R, Rogol AD, Kaiser DL, Rivier J, Vale W, Thorner MO. Stimulation of growth hormone (GH) and somatomedin C in idiopathic GH-deficient subjects by intermittent pulsatile administration of synthetic human pancreatic tumor GH-releasing factor. J Clin Endocrinol Metab. 1984 Jul;59(1):1–6. [PubMed]
  • Borges JL, Blizzard RM, Gelato MC, Furlanetto R, Rogol AD, Evans WS, Vance ML, Kaiser DL, MacLeod RM, Merriam GR, et al. Effects of human pancreatic tumour growth hormone releasing factor on growth hormone and somatomedin C levels in patients with idiopathic growth hormone deficiency. Lancet. 1983 Jul 16;2(8342):119–124. [PubMed]
  • Brazeau P, Vale W, Burgus R, Ling N, Butcher M, Rivier J, Guillemin R. Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone. Science. 1973 Jan 5;179(4068):77–79. [PubMed]
  • Chihara K, Minamitani N, Kaji H, Arimura A, Fujita T. Intraventricularly injected growth hormone stimulates somatostatin release into rat hypophysial portal blood. Endocrinology. 1981 Dec;109(6):2279–2281. [PubMed]
  • Copinschi G, Wegienka LC, Hane S, Forsham PH. Effect of arginine on serum levels of insulin and growth hormone in obese subjects. Metabolism. 1967 Jun;16(6):485–491. [PubMed]
  • Cremer GM, Bilstad JM, Faiman C, Moxness KE. Circulating levels of anterior pituitary hormones and insulin after arginine infusion. Mayo Clin Proc. 1968 Nov;43(11):776–782. [PubMed]
  • Cryer PE, Daughaday WH. Diabetic ketosis. Serial plasma growth hormone concentrations during therapy. Diabetes. 1970 Jul;19(7):519–523. [PubMed]
  • Davies RR, Turner S, Johnston DG. Oral glucose inhibits growth hormone secretion induced by human pancreatic growth hormone releasing factor 1-44 in normal man. Clin Endocrinol (Oxf) 1984 Oct;21(4):477–481. [PubMed]
  • Davies RR, Turner SJ, Parkin JM, Johnston DG. The response of normal subjects and patients with idiopathic growth hormone deficiency to continuous infusion of human pancreatic growth hormone releasing factor 1-44. Clin Endocrinol (Oxf) 1984 Nov;21(5):569–574. [PubMed]
  • Frantz AG, Rabkin MT. Effects of estrogen and sex difference on secretion of human growth hormone. J Clin Endocrinol Metab. 1965 Nov;25(11):1470–1480. [PubMed]
  • Frohman LA, Thominet JL, Webb CB, Vance ML, Uderman H, Rivier J, Vale W, Thorner MO. Metabolic clearance and plasma disappearance rates of human pancreatic tumor growth hormone releasing factor in man. J Clin Invest. 1984 May;73(5):1304–1311. [PMC free article] [PubMed]
  • Gomez-Pan A, Tunbridge WM, Duns A, Hall R, Besser GM, Coy DH, Schally AV, Kastin AJ. Hypothalamic hormone interaction in acromegaly. Clin Endocrinol (Oxf) 1975 Sep;4(5):455–460. [PubMed]
  • Grossman A, Savage MO, Lytras N, Preece MA, Sueiras-Diaz J, Coy DH, Rees LH, Besser GM. Responses to analogues of growth hormone-releasing hormone in normal subjects, and in growth-hormone deficient children and young adults. Clin Endocrinol (Oxf) 1984 Sep;21(3):321–330. [PubMed]
  • Grossman A, Savage MO, Wass JA, Lytras N, Sueiras-Diaz J, Coy DH, Besser GM. Growth-hormone-releasing factor in growth hormone deficiency: demonstration of a hypothalamic defect in growth hormone release. Lancet. 1983 Jul 16;2(8342):137–138. [PubMed]
  • Guillemin R, Brazeau P, Böhlen P, Esch F, Ling N, Wehrenberg WB. Growth hormone-releasing factor from a human pancreatic tumor that caused acromegaly. Science. 1982 Nov 5;218(4572):585–587. [PubMed]
  • Guillemin R, Gerich JE. Somatostatin: physiological and clinical significance. Annu Rev Med. 1976;27:379–388. [PubMed]
  • Schwarz E, Hansen ER. Tilslutningen til den regelmaessige ungdomstandpleje i 1973 belyst ved en undersøgelse af vaernepligtige. Fra Sundhedsstyr. 1973 Sep;6(15):175–passim. [PubMed]
  • Hansen AP. Normalization of growth hormone hyperresponse to exercise in juvenile diabetics after "normalization" of blood sugar. J Clin Invest. 1971 Sep;50(9):1806–1811. [PMC free article] [PubMed]
  • Laron Z, Keret R, Bauman B, Pertzelan A, Ben-Zeev Z, Olsen DB, Comaru-Schally AM, Schally AV. Differential diagnosis between hypothalamic and pituitary hGH deficiency with the aid of synthetic GH-RH 1-44. Clin Endocrinol (Oxf) 1984 Jul;21(1):9–12. [PubMed]
  • Martin JB. Neural regulation of growth hormone secretion. N Engl J Med. 1973 Jun 28;288(26):1384–1393. [PubMed]
  • Melmed S, Braunstein GD, Horvath E, Ezrin C, Kovacs K. Pathophysiology of acromegaly. Endocr Rev. 1983 Summer;4(3):271–290. [PubMed]
  • Merimee TJ, Gardner DF, Zapf J, Froesch ER. Effect of glycemic control on serum insulin-like growth factors in diabetes mellitus. Diabetes. 1984 Aug;33(8):790–793. [PubMed]
  • Miki N, Ono M, Shizume K. Evidence that opiatergic and alpha-adrenergic mechanisms stimulate rat growth hormone release via growth hormone-releasing factor (GRF). Endocrinology. 1984 May;114(5):1950–1952. [PubMed]
  • Penny ES, Penman E, Price J, Rees LH, Sopwith AM, Wass JA, Lytras N, Besser GM. Circulating growth hormone releasing factor concentrations in normal subjects and patients with acromegaly. Br Med J (Clin Res Ed) 1984 Aug 25;289(6443):453–455. [PMC free article] [PubMed]
  • Plotnick LP, Thompson RG, Kowarski A, de Lacerda L, Migeon CJ, Blizzard RM. Circadian variation of integrated concentration of growth hormone in children and adults. J Clin Endocrinol Metab. 1975 Feb;40(2):240–247. [PubMed]
  • Reichlin S. Somatostatin. N Engl J Med. 1983 Dec 15;309(24):1495–1501. [PubMed]
  • Rimoin DL, Schechter JE. Histological and ultrastructural studies in isolated growth hormone deficiency. J Clin Endocrinol Metab. 1973 Nov;37(5):725–735. [PubMed]
  • Rivier J, Spiess J, Thorner M, Vale W. Characterization of a growth hormone-releasing factor from a human pancreatic islet tumour. Nature. 1982 Nov 18;300(5889):276–278. [PubMed]
  • Santiago JV, Clarke WL, Shah SD, Cryer PE. Epinephrine, norepinephrine, glucagon, and growth hormone release in association with physiological decrements in the plasma glucose concentration in normal and diabetic man. J Clin Endocrinol Metab. 1980 Oct;51(4):877–883. [PubMed]
  • Schriock EA, Lustig RH, Rosenthal SM, Kaplan SL, Grumbach MM. Effect of growth hormone (GH)-releasing hormone (GRH) on plasma GH in relation to magnitude and duration of GH deficiency in 26 children and adults with isolated GH deficiency or multiple pituitary hormone deficiencies: evidence for hypothalamic GRH deficiency. J Clin Endocrinol Metab. 1984 Jun;58(6):1043–1049. [PubMed]
  • Sharp PS, Foley K, Kohner EM. Evidence for a central abnormality in the regulation of growth hormone secretion in insulin-dependent diabetes. Diabet Med. 1984 Sep;1(3):205–208. [PubMed]
  • Spiess J, Rivier J, Vale W. Characterization of rat hypothalamic growth hormone-releasing factor. Nature. 1983 Jun 9;303(5917):532–535. [PubMed]
  • Takano K, Hizuka N, Shizume K, Asakawa K, Miyakawa M, Hirose N, Shibasaki T, Ling NC. Plasma growth hormone (GH) response to GH-releasing factor in normal children with short stature and patients with pituitary dwarfism. J Clin Endocrinol Metab. 1984 Feb;58(2):236–241. [PubMed]
  • Tannenbaum GS. Evidence for autoregulation of growth hormone secretion via the central nervous system. Endocrinology. 1980 Dec;107(6):2117–2120. [PubMed]
  • Tannenbaum GS, Epelbaum J, Colle E, Brazeau P, Martin JB. Antiserum to somatostatin reverses starvation-induced inhibition of growth hormone but not insulin secretion. Endocrinology. 1978 Jun;102(6):1909–1914. [PubMed]
  • Thorner MO, Perryman RL, Cronin MJ, Rogol AD, Draznin M, Johanson A, Vale W, Horvath E, Kovacs K. Somatotroph hyperplasia. Successful treatment of acromegaly by removal of a pancreatic islet tumor secreting a growth hormone-releasing factor. J Clin Invest. 1982 Nov;70(5):965–977. [PMC free article] [PubMed]
  • Thorner MO, Perryman RL, Cronin MJ, Rogol AD, Draznin M, Johanson A, Vale W, Horvath E, Kovacs K. Somatotroph hyperplasia. Successful treatment of acromegaly by removal of a pancreatic islet tumor secreting a growth hormone-releasing factor. J Clin Invest. 1982 Nov;70(5):965–977. [PMC free article] [PubMed]
  • Wehrenberg WB, Brazeau P, Luben R, Böhlen P, Guillemin R. Inhibition of the pulsatile secretion of growth hormone by monoclonal antibodies to the hypothalamic growth hormone releasing factor (GRF). Endocrinology. 1982 Dec;111(6):2147–2148. [PubMed]
  • Wood SM, Ch'ng JL, Adams EF, Webster JD, Joplin GF, Mashiter K, Bloom SR. Abnormalities of growth hormone release in response to human pancreatic growth hormone releasing factor (GRF (1-44) ) in acromegaly and hypopituitarism. Br Med J (Clin Res Ed) 1983 May 28;286(6379):1687–1691. [PMC free article] [PubMed]

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