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J R Soc Med. 1985 March; 78(3): 207–210.
PMCID: PMC1289635

Prognostic value of tissue polypeptide antigen in urological neoplasia.


The prognostic importance of tissue polypeptide antigen (TPA) in urine samples of patients with urological cancers has been evaluated. TPA concentration correlated well both with the stage of the disease and survival. A simple score system was devised. There was very significant worsening of the prognosis with increasing score.

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Selected References

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  • Kumar S, Costello CB, Glashan RW, Björklund B. The clinical significance of tissue polypeptide antigen (TPA) in the urine of bladder cancer patients. Br J Urol. 1981 Dec;53(6):578–581. [PubMed]
  • Kumar S, Wilson P, Brenchley P, Taylor G, Björklund B, Eklund G. Frequent elevation of tissue polypeptide antigen in the sera of workers exposed to bladder carcinogens. Int J Cancer. 1978 Nov 15;22(5):542–545. [PubMed]
  • Redelius P, Lüning B, Björklund B. Chemical studies of tissue polypeptide antigen (TPA). II. Partial amino acid sequences of cyanogen bromide fragments of TPA subunit B1. Acta Chem Scand B. 1980;34(4):265–273. [PubMed]

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