PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of jrsocmedLink to Publisher's site
 
J R Soc Med. 1985 March; 78(3): 197–202.
PMCID: PMC1289633

Low-dose 131I in treatment of Graves' disease.

Abstract

One hundred and sixty-four patients with Graves' disease were treated with low-dose radioiodine (2 mCi), with a mean follow up of 4 1/2 years. At this time 74 (45%) were euthyroid having had a single dose, with a total of 131 (80%) being controlled with one or more doses. Three (2%) were still toxic but their mean follow up was only 3 years. Thirty (18%) were rendered hypothyroid, two-thirds of these after a single dose of 2 mCi 131I. The one-year incidence of hypothyroidism was 6%, with an incidence at 6 years of 20%. Previous surgery, medical treatment and thyroid antibody status appeared to have no influence on the outcome.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (778K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Beierwaltes WH. The treatment of hyperthyroidism with iodine-131. Semin Nucl Med. 1978 Jan;8(1):95–103. [PubMed]
  • BELING U, EINHORN J. Incidence of hypothyroidism and recurrences following I-131 treatment of hyperthyroidism. Acta radiol. 1961 Oct;56:275–288. [PubMed]
  • Best JD, Chan V, Khoo R, Teng CS, Wang C, Yeung RT. Incidence of hypothyroidism after radioactive iodine therapy for thyrotoxicosis in Hong Kong Chinese. Clin Radiol. 1981 Jan;32(1):57–61. [PubMed]
  • Blair AL, Lowe DC, Hadden DR, Weaver JA, Montgomery DA. Long term follow up of patients treated for hyperthyroidism with low dose radioactive iodine. Ulster Med J. 1980;49(1):71–78. [PMC free article] [PubMed]
  • Cevallos JL, Hagen GA, Maloof F, Chapman EM. Low-dosage 131-I therapy of thyrotoxicosis (diffuse goiters). A five-year follow-up study. N Engl J Med. 1974 Jan 17;290(3):141–143. [PubMed]
  • Dobyns BM, Sheline GE, Workman JB, Tompkins EA, McConahey WM, Becker DV. Malignant and benign neoplasms of the thyroid in patients treated for hyperthyroidism: a report of the cooperative thyrotoxicosis therapy follow-up study. J Clin Endocrinol Metab. 1974 Jun;38(6):976–998. [PubMed]
  • DUNN JT, CHAPMAN EM. RISING INCIDENCE OF HYPOTHYROIDISM AFTER RADIOACTIVE-IODINE THERAPY IN THYROTOXICOSIS. N Engl J Med. 1964 Nov 12;271:1037–1042. [PubMed]
  • Glennon JA, Gordon ES, Sawin CT. Hypothyroidism after low-dose 131 I treatment of hyperthyroidism. Ann Intern Med. 1972 May;76(5):721–723. [PubMed]
  • Goolden AW, Fraser TR. Treatment of thyrotoxicosis with low doses of radioactive iodine. Br Med J. 1969 Aug 23;3(5668):442–443. [PMC free article] [PubMed]
  • Hagen GA, Ouellette RP, Chapman EM. Comparison of high and low dosage levels of 131-I in the treatment of thyrotoxicosis. N Engl J Med. 1967 Sep 14;277(11):559–562. [PubMed]
  • Hamada N, Ito K, Mimura T, Momotani N, Nishikawa Y, Ino E, Ban Y, Tsuchiya T. [Longsterm results of 131I treatment of hyperthyroidism--factors influencing the incidence of hypothyroidism (author's transl)]. Kaku Igaku. 1979 Dec;16(8):1343–1353. [PubMed]
  • Jafiol C, Baldet L, Papachristou C, Lavit C, Mirouze J. Traitement de la maladie de Basedow par l'association de faibles doses d'iode radioactif et d'antithyroïdiens de synthèse. A propose de 330 cas aven un recul de 20 ans. Ann Endocrinol (Paris) 1980 Nov-Dec;41(6):593–596. [PubMed]
  • Kalk WJ, Durbach D, Kantor S, Levin J. Very low doses of radio-iodine for hyperthyroidism. Failure to prevent a high incidence of early hypothyroidism. S Afr Med J. 1980 Mar 29;57(13):479–482. [PubMed]
  • Lundell G, Holm LE. Hypothyroidism following 131I therapy for hyperthyroidism in relation to immunologic parameters. Acta Radiol Oncol. 1980;19(6):449–454. [PubMed]
  • MacFarlane IA, Shalet SM, Beardwell CG, Khara JS. Transient hypothyroidism after iodine-131 treatment for thyrotoxicosis. Br Med J. 1979 Aug 18;2(6187):421–421. [PMC free article] [PubMed]
  • Nofal MM, Beierwaltes WH, Patno ME. Treatment of hyperthyroidism with sodium iodide I-131. JAMA. 1966 Aug 22;197(8):605–610. [PubMed]
  • Rapoport B, Caplan R, DeGroot LJ. Low-dose sodium iodide I 131 therapy in Graves disease. JAMA. 1973 Jun 18;224(12):1610–1613. [PubMed]
  • Saenger EL, Thoma GE, Tompkins EA. Incidence of leukemia following treatment of hyperthyroidism. Preliminary report of the Cooperative Thyrotoxicosis Therapy Follow-Up Study. JAMA. 1968 Sep 16;205(12):855–862. [PubMed]
  • Safa AM, Schumacher OP, Rodriguez-Antunez A. Long-term follow-up results in children and adolescents treated with radioactive iodine (131I) for hyperthyroidism. N Engl J Med. 1975 Jan 23;292(4):167–171. [PubMed]
  • San Marco JL, Tobiana F, Dupin B, Simonin R. Le traitement de la maladie de Basedow par l'iode radio-actif. Surveillance de 277 patients de l à 23 ans. Ann Endocrinol (Paris) 1980 Nov-Dec;41(6):597–600. [PubMed]
  • Sawers JS, Toft AD, Irvine WJ, Brown NS, Seth J. Transient hypothyroidism after iodine-131 treatment of thyrotoxicosis. J Clin Endocrinol Metab. 1980 Feb;50(2):226–229. [PubMed]
  • Smith RN, Wilson GM. Clinical trial of different doses of 131-I in treatment of thyrotoxicosis. Br Med J. 1967 Jan 21;1(5533):129–132. [PMC free article] [PubMed]
  • Sugrue D, McEvoy M, Feely J, Drury MI. Hyperthyroidism in the land of Graves: results of treatment by surgery, radio-iodine and carbimazole in 837 cases. Q J Med. 1980 Winter;49(193):51–61. [PubMed]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press