PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of jrsocmedLink to Publisher's site
 
J R Soc Med. 1985 January; 78(1): 47–55.
PMCID: PMC1289545

Immune complex-associated deafness: preliminary communication.

Abstract

During the last year patients presenting with progressive bilateral or sudden sensorineural deafness of unknown aetiology have been investigated for possible abnormal immune activity. Twenty-six cases are reported in which significantly raised circulating immune complexes were present, together with 2 cases of clinical autoimmune deafness where the complexes were normal. Thirty-six control subjects were also studied. Following a review of the clinical features, the pathogenesis of this new association with sensorineural deafness is discussed. In some cases the aetiology is probably autoimmune, and in others related to infection. In certain patients the deafness has been partly reversed by medical treatment with systemic steroids or plasma exchange. It is hypothesized that circulating immune complexes may reflect a previously unrecognized final common pathophysiological pathway in a variety of cochleovestibular disorders.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.1M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • UCLA conference. Circulating immune complexes: their immunochemistry, detection, and importance. Ann Intern Med. 1979 Sep;91(3):430–440. [PubMed]
  • Chia D, Barnett EV, Yamagata J, Knutson D, Restivo C, Furst D. Quantitation and characterization of soluble immune complexes precipitated from sera by polyethylene glycol (PEG). Clin Exp Immunol. 1979 Sep;37(3):399–407. [PubMed]
  • Dawkins RS, Sharp M, Morrison AW. Steroid treatment in congenital syphilitic deafness. J Laryngol Otol. 1968 Dec;82(12):1095–1107. [PubMed]
  • Digeon M, Laver M, Riza J, Bach JF. Detection of circulating immune complexes in human sera by simplified assays with polyethylene glycol. J Immunol Methods. 1977;16(2):165–183. [PubMed]
  • HAHN RD, RODIN P, HASKINS HL. Treatment of neural deafness with prednisone. J Chronic Dis. 1962 Apr;15:395–409. [PubMed]
  • Hawkins JE., Jr Microcirculation in the labyrinth. Arch Otorhinolaryngol. 1976 Sep 16;212(4):241–251. [PubMed]
  • Hughes GB, Kinney SE, Barna BP, Calabrese LH. Autoimmune reactivity in Ménière's disease: a preliminary report. Laryngoscope. 1983 Apr;93(4):410–417. [PubMed]
  • Hughes GB, Kinney SE, Barna BP, Tomsak RL, Calabrese LH. Autoimmune reactivity in Cogan's syndrome: a preliminary report. Otolaryngol Head Neck Surg. 1983 Feb;91(1):24–32. [PubMed]
  • Kanzaki J, Ouchi T. Steroid-responsive bilateral sensorineural hearing loss and immune complexes. Arch Otorhinolaryngol. 1981;230(1):5–9. [PubMed]
  • Karmody CS, Schuknecht HF. Deafness in congenital syphilis. Arch Otolaryngol. 1966 Jan;83(1):18–27. [PubMed]
  • Mancini G, Carbonara AO, Heremans JF. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. [PubMed]
  • McCabe BF. Autoimmune sensorineural hearing loss. Ann Otol Rhinol Laryngol. 1979 Sep-Oct;88(5 Pt 1):585–589. [PubMed]
  • Morrison AW. Management of severe deafness in adults. The otologist's contribution. Proc R Soc Med. 1969 Sep;62(9):959–965. [PMC free article] [PubMed]
  • Plotz PH. Studies on immune complexes. Arthritis Rheum. 1982 Oct;25(10):1151–1155. [PubMed]
  • Stephens SD, Luxon L, Hinchcliffe R. Immunological disorders and auditory lesions. Audiology. 1982;21(2):128–148. [PubMed]
  • Theofilopoulos AN, Dixon FJ. The biology and detection of immune complexes. Adv Immunol. 1979;28:89–220. [PubMed]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press