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The correspondence on immunotherapy for cancer1,2 revives ideas first put forward in your own pages by Richards in 19883. The methods outlined regarded as unorthodox at the time, included immunotherapy and local debulking surgery—these being followed by a highly supportive regimen. In twenty years of its use I have not seen this regime improved upon. It remains now only for the enzyme components and one or two others to be added to current thinking. At the time, I gather, Richards' discussion paper drew only two responses. Remarkable? Perhaps—but now well worth another read.