Search tips
Search criteria 


Logo of brheartjLink to Publisher's site
Br Heart J. 1988 June; 59(6): 672–679.
PMCID: PMC1276874

Influence of aging on Doppler echocardiographic indices of left ventricular diastolic function.


The influence of age on six Doppler echocardiographic indices of left ventricular diastolic function was assessed in 86 normal volunteers aged from 20 to 74 years (mean 36). Five of the six indices showed a linear relation with age. Duration of isovolumic relaxation and maximal late diastolic (atrial) flow velocity increased significantly with age (r = 0.34 and r = 0.69), respectively). Conversely, maximal early diastolic flow velocity, the rate of decrease (deceleration) of flow velocity in early diastole, and the ratio between maximal early and late diastolic flow velocities decreased significantly with age (r = -0.30, r = -0.40, and r = -0.63, respectively). Duration of the early diastolic flow velocity peak did not show a linear relation with age (r = 0.04). Comparison of Doppler indices of diastolic performance among different age groups (20 to 29 years, 30 to 49 years, and 50 to 74 years) also showed an influence of aging on these diastolic variables. Isovolumic relaxation was significantly longer in older subjects than in either the intermediate or the younger age groups. In addition, both the rate of decrease of flow velocity in early diastole and the ratio between maximal early and late diastolic flow velocities were significantly reduced in older subjects. Multivariate linear regression analysis showed that after adjustment for left ventricular wall thickness and cavity dimension, percentage systolic shortening, and heart rate, age continued to correlate significantly with most Doppler indices of diastolic function. The isovolumic relaxation phase and the early and late filling phases of diastole, as assessed by Doppler echocardiography, are importantly and independently affected by aging. Hence the effects of age should be taken into account when the normal limits for Doppler indices of left ventricular diastolic function are defined.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.6M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Images in this article

Click on the image to see a larger version.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Miyatake K, Okamoto M, Kinoshita N, Owa M, Nakasone I, Sakakibara H, Nimura Y. Augmentation of atrial contribution to left ventricular inflow with aging as assessed by intracardiac Doppler flowmetry. Am J Cardiol. 1984 Feb 1;53(4):586–589. [PubMed]
  • Fujii J, Yazaki Y, Sawada H, Aizawa T, Watanabe H, Kato K. Noninvasive assessment of left and right ventricular filling in myocardial infarction with a two-dimensional Doppler echocardiographic method. J Am Coll Cardiol. 1985 May;5(5):1155–1160. [PubMed]
  • Snider AR, Gidding SS, Rocchini AP, Rosenthal A, Dick M, 2nd, Crowley DC, Peters J. Doppler evaluation of left ventricular diastolic filling in children with systemic hypertension. Am J Cardiol. 1985 Dec 1;56(15):921–926. [PubMed]
  • Rokey R, Kuo LC, Zoghbi WA, Limacher MC, Quinones MA. Determination of parameters of left ventricular diastolic filling with pulsed Doppler echocardiography: comparison with cineangiography. Circulation. 1985 Mar;71(3):543–550. [PubMed]
  • Spirito P, Maron BJ, Bonow RO. Noninvasive assessment of left ventricular diastolic function: comparative analysis of Doppler echocardiographic and radionuclide angiographic techniques. J Am Coll Cardiol. 1986 Mar;7(3):518–526. [PubMed]
  • Takenaka K, Dabestani A, Gardin JM, Russell D, Clark S, Allfie A, Henry WL. Left ventricular filling in hypertrophic cardiomyopathy: a pulsed Doppler echocardiographic study. J Am Coll Cardiol. 1986 Jun;7(6):1263–1271. [PubMed]
  • Spirito P, Maron BJ, Bellotti P, Chiarella F, Vecchio C. Noninvasive assessment of left ventricular diastolic function: comparative analysis of pulsed Doppler ultrasound and digitized M-mode echocardiography. Am J Cardiol. 1986 Oct 1;58(9):837–843. [PubMed]
  • Louie EK, Rich S, Brundage BH. Doppler echocardiographic assessment of impaired left ventricular filling in patients with right ventricular pressure overload due to primary pulmonary hypertension. J Am Coll Cardiol. 1986 Dec;8(6):1298–1306. [PubMed]
  • Friedman BJ, Drinkovic N, Miles H, Shih WJ, Mazzoleni A, DeMaria AN. Assessment of left ventricular diastolic function: comparison of Doppler echocardiography and gated blood pool scintigraphy. J Am Coll Cardiol. 1986 Dec;8(6):1348–1354. [PubMed]
  • Bryg RJ, Williams GA, Labovitz AJ. Effect of aging on left ventricular diastolic filling in normal subjects. Am J Cardiol. 1987 Apr 15;59(9):971–974. [PubMed]
  • Hirota Y. A clinical study of left ventricular relaxation. Circulation. 1980 Oct;62(4):756–763. [PubMed]
  • Derman U. Changes of the mitral echocardiogram with ageing and the influence of atherosclerotic risk factors. Atherosclerosis. 1972 May-Jun;15(3):349–357. [PubMed]
  • Luisada AA, Watanabe K, Bhat PK, Rao DB, Knighten V. Correlates of the echocardiographic waves of the mitral valve in normal subjects of various ages. J Am Geriatr Soc. 1975 May;23(5):216–223. [PubMed]
  • Gerstenblith G, Frederiksen J, Yin FC, Fortuin NJ, Lakatta EG, Weisfeldt ML. Echocardiographic assessment of a normal adult aging population. Circulation. 1977 Aug;56(2):273–278. [PubMed]
  • Gardin JM, Henry WL, Savage DD, Ware JH, Burn C, Borer JS. Echocardiographic measurements in normal subjects: evaluation of an adult population without clinically apparent heart disease. J Clin Ultrasound. 1979 Dec;7(6):439–447. [PubMed]
  • Miller TR, Grossman SJ, Schectman KB, Biello DR, Ludbrook PA, Ehsani AA. Left ventricular diastolic filling and its association with age. Am J Cardiol. 1986 Sep 1;58(6):531–535. [PubMed]
  • Gaasch WH, Cole JS, Quinones MA, Alexander JK. Dynamic determinants of letf ventricular diastolic pressure-volume relations in man. Circulation. 1975 Feb;51(2):317–323. [PubMed]
  • Grossman W, McLaurin LP. Diastolic properties of the left ventricle. Ann Intern Med. 1976 Mar;84(3):316–326. [PubMed]
  • Upton MT, Gibson DG, Brown DJ. Echocardiographic assessment of abnormal left ventricular relaxation in man. Br Heart J. 1976 Oct;38(10):1001–1009. [PMC free article] [PubMed]
  • Glantz SA, Parmley WW. Factors which affect the diastolic pressure-volume curve. Circ Res. 1978 Feb;42(2):171–180. [PubMed]
  • Frederiksen JW, Weiss JL, Weisfeldt ML. Time constant of isovolumic pressure fall: determinants in the working left ventricle. Am J Physiol. 1978 Dec;235(6):H701–H706. [PubMed]
  • Carroll JD, Hess OM, Hirzel HO, Krayenbuehl HP. Dynamics of left ventricular filling at rest and during exercise. Circulation. 1983 Jul;68(1):59–67. [PubMed]
  • Brutsaert DL, Rademakers FE, Sys SU. Triple control of relaxation: implications in cardiac disease. Circulation. 1984 Jan;69(1):190–196. [PubMed]
  • O'Rourke MF, Yaginuma T. Wave reflections and the arterial pulse. Arch Intern Med. 1984 Feb;144(2):366–371. [PubMed]

Articles from British Heart Journal are provided here courtesy of BMJ Publishing Group