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From:
Published online May 2, 2002. doi: 10.1186/ar420
Table 1
Characteristics of the two patient cohorts.
Retrospective studyProspective cohort
Number of patients (female/male)94 (73/14)70 (53/17)
Age at disease onset (years) [mean (range)]45.8 (20–77)51.9 (19–74)
Disease duration (years) [mean (range)]16.7 (1.4–61)4.44 (4.1–6.7)
ESR (mm/h) [mean (range)]34.2 (2–100)23.8 (3–76)
C-reactive protein (mg/l) [mean (range)]34.3 (0–190)13.1 (0–116.5)
Patients positive for RF IgM [n (%)]51 (54.3)42 (60)
RF IgM concentration (IU/ml) [mean (range)]344.6 (0–3680)245.2 (0–3430)
Patients positive for RF IgA [n (%)]52 (55.3)3 (48.6)
RF IgA concentration (IU/ml) [mean (range)]105.6 (0–600)71.8 (0–600)
Patients positive for ANF [n (%)]56 (59.5)55 (78.6)
Extra-articular manifestations
 Rheumatoid nodules [n (%)]28 (29.8)5 (7.1)
 Keratokonjunctivitis sicca [n (%)]30 (32)10 (14.3)
 Polyserositis [n (%)]2 (2.1)0
 Interstitial pulmonary fibrosis [n (%)]1 (1.1)0
Immunogenetics
 DRB1*01+ [n (%)]21 (22)19 (27.1)
 SE+ DR4+ [n (%)]46 (49)32 (45.7)
 SE+ DR4+ homozygotes [n (%)]15 (16.0)8 (11.4)
 SE+ [n (%)]67 (71)51 (72.8)
 SE compound homozygotes [n (%)]24 (25.5)12 (17.1)
Therapy
 Methotrexate5756
 Cyclosporine A96
 Azathioprine60
 Chlorochine/sulfasalazine/gold salts intramuscularly65
 Cyclophosphamide70
 No DMARD97
 Number of DMARD used [mean (range)]2 (0–5)1 (0–3)
ANF, antinuclear factors; ESR, erythrocyte sedimentation rate; RF, rheumatoid factor; SE+, presence of the shared epitope on a DRB1*01 or DRB1*04 allele; SE+ DR4+, presence of the shared epitope on a DRB1*04 allele; SE compound homozygotes, presence of SE on both chromosomes. Clinical characterization at the time of flow cytometric analysis, immunogenetic markers and disease-modifying antirheumatic drugs (DMARDs) received in the two study populations.
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