PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of bmjcredBMJ helping doctors make better decisionsSearchLatest content
 
Br Med J (Clin Res Ed). Apr 18, 1987; 294(6578): 997–1000.
PMCID: PMC1246155
Silica exposure and rheumatoid arthritis: a follow up study of granite workers 1940-81.
M Klockars, R S Koskela, E Järvinen, P J Kolari, and A Rossi
Institute of Occupational Health, Helsinki, Finland.
Abstract
The incidence and prevalence of subjects awarded disability pensions and the prevalence of subjects receiving free medicines because of rheumatoid arthritis were studied in a Finnish cohort of 1026 granite workers hired between 1940 and 1971 and followed up until 31 December 1981. The incidence of awards of disability pensions because of rheumatoid arthritis during 1969-81, the prevalence of rheumatoid arthritis on 31 December 1981, and the prevalence of subjects receiving free medicines for rheumatoid arthritis at the end of 1981 were significantly higher among the granite workers than in the general male population of the same age. Retrospective analysis of the records of all patients with rheumatoid arthritis in the cohort showed a predominance of a severe, serologically positive and erosive form of rheumatoid arthritis, usually with an age at onset of 50 or over. The possible aetiological or pathophysiological role of granite dust in rheumatoid arthritis may be based on the effects of quartz on the immune system.
Full text
Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (890K), or click on a page image below to browse page by page.
Articles from British Medical Journal (Clinical Research Ed.) are provided here courtesy of
BMJ Publishing Group