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Environ Health Perspect. 2003 January; 111(1): 79–84.
PMCID: PMC1241309
Research Article

Exposure to indoor pesticides during pregnancy in a multiethnic, urban cohort.

Abstract

Evidence is growing that indoor pesticide exposure is of considerable magnitude in the United States and that pesticide concentrations may be especially high in urban areas. Of particular concern is exposure of pregnant women because animal data suggest that exposure to pesticides during pregnancy and early life may impair neurodevelopment in the offspring. To investigate the relationship between prenatal exposure to indoor pesticides and infant growth and development, we are conducting a prospective, multiethnic cohort study of mothers and infants delivered at Mount Sinai Hospital in New York City. This article provides data on pesticide exposure based on questionnaire items and analysis of maternal urinary metabolite levels among 386 women. Both the questionnaire and laboratory data revealed that exposure to indoor pesticides was considerable. The proportion of women estimated from questionnaire data as having been exposed during pregnancy to indoor pesticides (approximately 70%) was somewhat lower than the 80-90% of American households who reportedly used pesticides in previous surveys, but some of the latter surveys included both indoor and outdoor pesticide use. Urinary metabolite levels of 3,5,6-trichloro-2-pyridinol (TCPy; median = 11.3 micro g/g creatinine), phenoxybenzoic acid (PBA; median =19.3 micro g/g creatinine), and pentachlorophenol (PCP; median =7.3 micro g/g creatinine) were higher than those reported in other studies of adults in the United States. Furthermore, no associations were evident between the pesticide questionnaire data and the urinary metabolites. Assessments of sociodemographic and building characteristics with questionnaire data and the metabolite levels revealed no consistent trends. Significant temporal variations were observed for urinary PBA but not TCPy or PCP. The temporal variations for PBA were consistent with seasonal spraying of pyrethroid pesticides. These data underscore the need to assess the potentially adverse effects of pesticide exposure on fetuses and infants and the importance of finding alternative methods for pest management to reduce pesticide exposures.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Lewis RG, Fortmann RC, Camann DE. Evaluation of methods for monitoring the potential exposure of small children to pesticides in the residential environment. Arch Environ Contam Toxicol. 1994 Jan;26(1):37–46. [PubMed]
  • Whitemore RW, Immerman FW, Camann DE, Bond AE, Lewis RG, Schaum JL. Non-occupational exposures to pesticides for residents of two U.S. cities. Arch Environ Contam Toxicol. 1994 Jan;26(1):47–59. [PubMed]
  • Landrigan PJ, Claudio L, Markowitz SB, Berkowitz GS, Brenner BL, Romero H, Wetmur JG, Matte TD, Gore AC, Godbold JH, et al. Pesticides and inner-city children: exposures, risks, and prevention. Environ Health Perspect. 1999 Jun;107 (Suppl 3):431–437. [PMC free article] [PubMed]
  • Adgate JL, Barr DB, Clayton CA, Eberly LE, Freeman NC, Lioy PJ, Needham LL, Pellizzari ED, Quackenboss JJ, Roy A, et al. Measurement of children's exposure to pesticides: analysis of urinary metabolite levels in a probability-based sample. Environ Health Perspect. 2001 Jun;109(6):583–590. [PMC free article] [PubMed]
  • Adgate JL, Kukowski A, Stroebel C, Shubat PJ, Morrell S, Quackenboss JJ, Whitmore RW, Sexton K. Pesticide storage and use patterns in Minnesota households with children. J Expo Anal Environ Epidemiol. 2000 Mar-Apr;10(2):159–167. [PubMed]
  • Whyatt Robin M, Camann David E, Kinney Patrick L, Reyes Andria, Ramirez Judy, Dietrich Jessica, Diaz Diurka, Holmes Darrell, Perera Frederica P. Residential pesticide use during pregnancy among a cohort of urban minority women. Environ Health Perspect. 2002 May;110(5):507–514. [PMC free article] [PubMed]
  • Fenske RA, Black KG, Elkner KP, Lee CL, Methner MM, Soto R. Potential exposure and health risks of infants following indoor residential pesticide applications. Am J Public Health. 1990 Jun;80(6):689–693. [PubMed]
  • Gurunathan S, Robson M, Freeman N, Buckley B, Roy A, Meyer R, Bukowski J, Lioy PJ. Accumulation of chlorpyrifos on residential surfaces and toys accessible to children. Environ Health Perspect. 1998 Jan;106(1):9–16. [PMC free article] [PubMed]
  • Hill RH, Jr, Head SL, Baker S, Gregg M, Shealy DB, Bailey SL, Williams CC, Sampson EJ, Needham LL. Pesticide residues in urine of adults living in the United States: reference range concentrations. Environ Res. 1995 Nov;71(2):99–108. [PubMed]
  • MacIntosh DL, Needham LL, Hammerstrom KA, Ryan PB. A longitudinal investigation of selected pesticide metabolites in urine. J Expo Anal Environ Epidemiol. 1999 Sep-Oct;9(5):494–501. [PubMed]
  • Fenske Richard A, Lu Chensheng, Barr Dana, Needham Larry. Children's exposure to chlorpyrifos and parathion in an agricultural community in central Washington State. Environ Health Perspect. 2002 May;110(5):549–553. [PMC free article] [PubMed]
  • Nolan RJ, Rick DL, Freshour NL, Saunders JH. Chlorpyrifos: pharmacokinetics in human volunteers. Toxicol Appl Pharmacol. 1984 Mar 30;73(1):8–15. [PubMed]
  • Leng G, Leng A, Kühn KH, Lewalter J, Pauluhn J. Human dose-excretion studies with the pyrethroid insecticide cyfluthrin: urinary metabolite profile following inhalation. Xenobiotica. 1997 Dec;27(12):1273–1283. [PubMed]
  • Uhl S, Schmid P, Schlatter C. Pharmacokinetics of pentachlorophenol in man. Arch Toxicol. 1986 Feb;58(3):182–186. [PubMed]
  • Chang MJ, Lin CY, Lo LW, Lin RS. Biological monitoring of exposure to chlorpyrifos by high performance liquid chromatography. Bull Environ Contam Toxicol. 1996 Mar;56(3):367–374. [PubMed]
  • Hill RH, Jr, Shealy DB, Head SL, Williams CC, Bailey SL, Gregg M, Baker SE, Needham LL. Determination of pesticide metabolites in human urine using an isotope dilution technique and tandem mass spectrometry. J Anal Toxicol. 1995 Sep;19(5):323–329. [PubMed]
  • Carrieri M, Trevisan A, Bartolucci GB. Adjustment to concentration-dilution of spot urine samples: correlation between specific gravity and creatinine. Int Arch Occup Environ Health. 2001 Jan;74(1):63–67. [PubMed]
  • Boeniger MF, Lowry LK, Rosenberg J. Interpretation of urine results used to assess chemical exposure with emphasis on creatinine adjustments: a review. Am Ind Hyg Assoc J. 1993 Oct;54(10):615–627. [PubMed]
  • Kutz FW, Cook BT, Carter-Pokras OD, Brody D, Murphy RS. Selected pesticide residues and metabolites in urine from a survey of the U.S. general population. J Toxicol Environ Health. 1992 Oct;37(2):277–291. [PubMed]
  • Seifert B, Becker K, Helm D, Krause C, Schulz C, Seiwert M. The German Environmental Survey 1990/1992 (GerES II): reference concentrations of selected environmental pollutants in blood, urine, hair, house dust, drinking water and indoor air. J Expo Anal Environ Epidemiol. 2000 Nov-Dec;10(6 Pt 1):552–565. [PubMed]
  • Heudorf U, Angerer J. Metabolites of pyrethroid insecticides in urine specimens: current exposure in an urban population in Germany. Environ Health Perspect. 2001 Mar;109(3):213–217. [PMC free article] [PubMed]
  • Baker SE, Barr DB, Driskell WJ, Beeson MD, Needham LL. Quantification of selected pesticide metabolites in human urine using isotope dilution high-performance liquid chromatography/tandem mass spectrometry. J Expo Anal Environ Epidemiol. 2000 Nov-Dec;10(6 Pt 2):789–798. [PubMed]
  • Lu C, Knutson DE, Fisker-Andersen J, Fenske RA. Biological monitoring survey of organophosphorus pesticide exposure among pre-school children in the Seattle metropolitan area. Environ Health Perspect. 2001 Mar;109(3):299–303. [PMC free article] [PubMed]

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