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West J Med. 1977 December; 127(6): 461–463.
PMCID: PMC1237915

Human Chorionic Gonadotropin (HCG) in the Treatment of Obesity

A Critical Assessment of the Simeons Method


Injections of human chorionic gonadotropin (HCG) have been claimed to aid in weight reduction by reducing hunger, and affecting mood as well as aiding in localized (spot) reduction. We have tested these claims in a double-blind randomized trial using injections of HCG or placebo. Weight loss was identical between the two groups, and there was no evidence for differential effects on hunger, mood or localized body measurements. Placebo injections, therefore, appear to be as effective as HCG in the treatment of obesity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • SIMEONS AT. The action of chorionic gonadotrophin in the obese. Lancet. 1954 Nov 6;267(6845):946–947. [PubMed]
  • Albrink MJ. Chorionic gonadotropin and obesity? Am J Clin Nutr. 1969 Jun;22(6):681–685. [PubMed]
  • Stein MR, Julis RE, Peck CC, Hinshaw W, Sawicki JE, Deller JJ., Jr Ineffectiveness of human chorionic gonadotropin in weight reduction: a double-blind study. Am J Clin Nutr. 1976 Sep;29(9):940–948. [PubMed]
  • Young RL, Fuchs RJ, Woltjen MJ. Chorionic gonadotropin in weight control. A double-blind crossover study. JAMA. 1976 Nov 29;236(22):2495–2497. [PubMed]
  • Silverstone JT, Turner P, Humpherson PL. Direct measurement of the anorectic activity of diethylpropion (Tenuate Dospan). J Clin Pharmacol J New Drugs. 1968 May-Jun;8(3):172–179. [PubMed]
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  • Asher WL, Harper HW. Effect of human chorionic gonadotrophin on weight loss, hunger, and feeling of well-being. Am J Clin Nutr. 1973 Feb;26(2):211–218. [PubMed]
  • Bray GA, Greenway FL. Pharmacological approaches to treating the obese patient. Clin Endocrinol Metab. 1976 Jul;5(2):455–479. [PubMed]
  • CARNE S. The action of chorionic gonadotrophin in the obese. Lancet. 1961 Dec 9;2(7215):1282–1284. [PubMed]

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