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West J Med. 1977 July; 127(1): 15–23.
PMCID: PMC1237671

Familial Mediterranean Fever

Recent Advances in Pathogenesis and Management

Abstract

The success of colchicine therapy in the management of familial Mediterranean fever has provided new direction to investigations into the pathogenesis of this disease. Examination of HLA antigen frequencies in 53 patients with familial Mediterranean fever and appropriate controls, as well as various immunologic studies have yielded no significant differences. However, B lymphocyte typing and assays for immune complexes, lymphokines and prostaglandins may be of potential interest. Preliminary studies indicate that leukocytes of patients with familial Mediterranean fever release increased amounts of lysozyme (P<0.01), when subjected to high temperatures, and of both lysozyme and myeloperoxidase at low osmotic concentrations. The known and potential effects of colchicine on leukocyte and cellular metabolism, and the current status of colchicine prophylaxis are reviewed. In patients receiving an optimum colchicine dose of 1.5 to 1.8 mg per day, side effects have been minimal and the frequency of attacks has been decreased significantly.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • SIEGAL S. FAMILIAL PAROXYSMAL POLYSEROSITIS. ANALYSIS OF FIFTY CASES. Am J Med. 1964 Jun;36:893–918. [PubMed]
  • HELLER H, SOHAR E, SHERF L. Familial Mediterranean fever. AMA Arch Intern Med. 1958 Jul;102(1):50–71. [PubMed]
  • Sohar E, Gafni J, Pras M, Heller H. Familial Mediterranean fever. A survey of 470 cases and review of the literature. Am J Med. 1967 Aug;43(2):227–253. [PubMed]
  • Schwabe AD, Peters RS. Familial Mediterranean Fever in Armenians. Analysis of 100 cases. Medicine (Baltimore) 1974 Nov;53(6):453–462. [PubMed]
  • Schlosstein L, Terasaki PI, Bluestone R, Pearson CM. High association of an HL-A antigen, W27, with ankylosing spondylitis. N Engl J Med. 1973 Apr 5;288(14):704–706. [PubMed]
  • FRENSDORFF A, SHIBOLET S, LAMPRECHT S, SOHAR E. PLASMA PROTEINS IN FAMILIAL MEDITERRANEAN FEVER. Clin Chim Acta. 1964 Aug;10:106–113. [PubMed]
  • Henson PM. Pathologic mechanisms in neutrophil-mediated injury. Am J Pathol. 1972 Sep;68(3):593–612. [PubMed]
  • Atkins E, Bodel P. Fever. N Engl J Med. 1972 Jan 6;286(1):27–34. [PubMed]
  • Malawista SE. Colchicine: a common mechanism for its anti-inflammatory and anti-mitotic effects. Arthritis Rheum. 1968 Apr;11(2):191–197. [PubMed]
  • Territo MC, Peters RS, Cline MJ. Leukocyte function in familial Mediterranean fever. Am J Hematol. 1976;1(3):307–311. [PubMed]
  • Dinarello CA, Chusid MJ, Fauci AS, Gallin JI, Dale DC, Wolff SM. Effect of prophylactic colchicine therapy on leukocyte function in patients with familial Mediterranean fever. Arthritis Rheum. 1976 May-Jun;19(3):618–622. [PubMed]
  • Goldfinger SE. Colchicine for familial Mediterranean fever. N Engl J Med. 1972 Dec 21;287(25):1302–1302. [PubMed]
  • Zemer D, Revach M, Pras M, Modan B, Schor S, Sohar E, Gafni J. A controlled trial of colchicine in preventing attacks of familial mediterranean fever. N Engl J Med. 1974 Oct 31;291(18):932–934. [PubMed]
  • Dinarello CA, Wolff SM, Goldfinger SE, Dale DC, Alling DW. Colchicine therapy for familial mediterranean fever. A double-blind trial. N Engl J Med. 1974 Oct 31;291(18):934–937. [PubMed]
  • Goldstein RC, Schwabe AD. Prophylactic colchicine therapy in familial Mediterranean fever. A controlled, double-blind study. Ann Intern Med. 1974 Dec;81(6):792–794. [PubMed]
  • Zemer D, Pras M, Sohar E, Gafni J. Letter: Colchicine in familial Mediterranean fever. N Engl J Med. 1976 Jan 15;294(3):170–171. [PubMed]

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