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Genitourin Med. 1995 August; 71(4): 212–215.
PMCID: PMC1195515

HIV-1 incidence and HIV-1 associated mortality in a cohort of urban factory workers in Tanzania.


OBJECTIVE--To determine HIV-1 incidence and HIV-1 associated mortality in a prospective cohort study. To determine whether the cohort is suitable for studies aiming to determine the impact of interventions on HIV-1 incidence. METHODS--The study population was a cohort of 1772 urban factory workers (1478 men and 294 women) in northwest Tanzania. The study took place from October 1991 to September 1993. Outcome measures were HIV-1 seroconversion and death. RESULTS--HIV-1 incidence was 1.2 (95% CI 0.7-2.0) per 100 person-years (pyr). Crude annual mortality was 4.9 per 100 pyr in those with and 0.3 in those without HIV-1 infection, giving an age and sex adjusted mortality ratio of 12.9 (95% CI 5.4-30.7). Of all deaths, 62% were attributable to HIV-1 infection. CONCLUSION--HIV-1 infection was a major public health problem, being the major cause of death in this adult population. At an HIV-1 incidence of 1.2 per 100 pyr, a large cohort size would be required to evaluate the impact of interventions on HIV-1 incidence.

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  • Dixon DO, Rida WN, Fast PE, Hoth DF. HIV vaccine trials: some design issues including sample size calculation. J Acquir Immune Defic Syndr. 1993 May;6(5):485–496. [PubMed]
  • Nkowane BM. Prevalence and incidence of HIV infection in Africa: a review of data published in 1990. AIDS. 1991;5 (Suppl 1):S7–15. [PubMed]
  • Mann JM, Francis H, Quinn TC, Bosenge N, Nzilambi N, Kabeya N, Baudoux M, Samba MN, Bodissa C, Behets F, et al. HIV seroincidence in a hospital worker population: Kinshasa, Zaïre. Ann Soc Belg Med Trop. 1986 Sep;66(3):245–250. [PubMed]
  • N'Galy B, Ryder RW, Bila K, Mwandagalirwa K, Colebunders RL, Francis H, Mann JM, Quinn TC. Human immunodeficiency virus infection among employees in an African hospital. N Engl J Med. 1988 Oct 27;319(17):1123–1127. [PubMed]
  • Cameron DW, Simonsen JN, D'Costa LJ, Ronald AR, Maitha GM, Gakinya MN, Cheang M, Ndinya-Achola JO, Piot P, Brunham RC, et al. Female to male transmission of human immunodeficiency virus type 1: risk factors for seroconversion in men. Lancet. 1989 Aug 19;2(8660):403–407. [PubMed]
  • Hira SK, Mangrola UG, Mwale C, Chintu C, Tembo G, Brady WE, Perine PL. Apparent vertical transmission of human immunodeficiency virus type 1 by breast-feeding in Zambia. J Pediatr. 1990 Sep;117(3):421–424. [PubMed]
  • Kamenga M, Ryder RW, Jingu M, Mbuyi N, Mbu L, Behets F, Brown C, Heyward WL. Evidence of marked sexual behavior change associated with low HIV-1 seroconversion in 149 married couples with discordant HIV-1 serostatus: experience at an HIV counselling center in Zaire. AIDS. 1991 Jan;5(1):61–67. [PubMed]
  • Allen S, Serufilira A, Bogaerts J, Van de Perre P, Nsengumuremyi F, Lindan C, Carael M, Wolf W, Coates T, Hulley S. Confidential HIV testing and condom promotion in Africa. Impact on HIV and gonorrhea rates. JAMA. 1992 Dec 16;268(23):3338–3343. [PubMed]
  • Allen S, Tice J, Van de Perre P, Serufilira A, Hudes E, Nsengumuremyi F, Bogaerts J, Lindan C, Hulley S. Effect of serotesting with counselling on condom use and seroconversion among HIV discordant couples in Africa. BMJ. 1992 Jun 20;304(6842):1605–1609. [PMC free article] [PubMed]
  • Killewo JZ, Sandstrom A, Bredberg Raden U, Mhalu FS, Biberfeld G, Wall S. Incidence of HIV-1 infection among adults in the Kagera region of Tanzania. Int J Epidemiol. 1993 Jun;22(3):528–536. [PubMed]
  • Laga M, Manoka A, Kivuvu M, Malele B, Tuliza M, Nzila N, Goeman J, Behets F, Batter V, Alary M, et al. Non-ulcerative sexually transmitted diseases as risk factors for HIV-1 transmission in women: results from a cohort study. AIDS. 1993 Jan;7(1):95–102. [PubMed]
  • Zekeng L, Feldblum PJ, Oliver RM, Kaptue L. Barrier contraceptive use and HIV infection among high-risk women in Cameroon. AIDS. 1993 May;7(5):725–731. [PubMed]
  • Wawer MJ, Sewankambo NK, Berkley S, Serwadda D, Musgrave SD, Gray RH, Musagara M, Stallings RY, Konde-Lule JK. Incidence of HIV-1 infection in a rural region of Uganda. BMJ. 1994 Jan 15;308(6922):171–173. [PMC free article] [PubMed]
  • Mulder DW, Nunn AJ, Wagner HU, Kamali A, Kengeya-Kayondo JF. HIV-1 incidence and HIV-1-associated mortality in a rural Ugandan population cohort. AIDS. 1994 Jan;8(1):87–92. [PubMed]
  • De Cock KM, Barrere B, Diaby L, Lafontaine MF, Gnaore E, Porter A, Pantobe D, Lafontant GC, Dago-Akribi A, Ette M, et al. AIDS--the leading cause of adult death in the West African City of Abidjan, Ivory Coast. Science. 1990 Aug 17;249(4970):793–796. [PubMed]
  • De Cock KM, Porter A, Odehouri K, Barrere B, Moreau J, Diaby L, Kouadio JC, Heyward WL. Rapid emergence of AIDS in Abidjan, Ivory Coast. Lancet. 1989 Aug 19;2(8660):408–411. [PubMed]
  • Gilks CF, Brindle RJ, Otieno LS, Simani PM, Newnham RS, Bhatt SM, Lule GN, Okelo GB, Watkins WM, Waiyaki PG, et al. Life-threatening bacteraemia in HIV-1 seropositive adults admitted to hospital in Nairobi, Kenya. Lancet. 1990 Sep 1;336(8714):545–549. [PubMed]
  • Hassig SE, Perriëns J, Baende E, Kahotwa M, Bishagara K, Kinkela N, Kapita B. An analysis of the economic impact of HIV infection among patients at Mama Yemo Hospital, Kinshasa, Zaire. AIDS. 1990 Sep;4(9):883–887. [PubMed]
  • Nelson AM, Hassig SE, Kayembe M, Okonda L, Mulanga K, Brown C, Kayembe K, Kalengayi MM, Mullick FG. HIV-1 seropositivity and mortality at University Hospital, Kinshasa, Zaire, 1987. AIDS. 1991 May;5(5):583–586. [PubMed]
  • Müller O, Moser R. HIV-1 disease in a Kampala Hospital 1985-89. Lancet. 1990 Jan 27;335(8683):236–237. [PubMed]
  • Lindan CP, Allen S, Serufilira A, Lifson AR, Van de Perre P, Chen-Rundle A, Batungwanayo J, Nsengumuremyi F, Bogaerts J, Hulley S. Predictors of mortality among HIV-infected women in Kigali, Rwanda. Ann Intern Med. 1992 Feb 15;116(4):320–328. [PubMed]
  • Anderson RM, May RM, Boily MC, Garnett GP, Rowley JT. The spread of HIV-1 in Africa: sexual contact patterns and the predicted demographic impact of AIDS. Nature. 1991 Aug 15;352(6336):581–589. [PubMed]
  • Anderson RM. Some aspects of sexual behaviour and the potential demographic impact of AIDS in developing countries. Soc Sci Med. 1992 Feb;34(3):271–280. [PubMed]
  • Gregson S, Garnett GP, Anderson RM. Is HIV-1 likely to become a leading cause of adult mortality in sub-Saharan Africa? J Acquir Immune Defic Syndr. 1994 Aug;7(8):839–852. [PubMed]
  • Barongo LR, Borgdorff MW, Mosha FF, Nicoll A, Grosskurth H, Senkoro KP, Newell JN, Changalucha J, Klokke AH, Killewo JZ, et al. The epidemiology of HIV-1 infection in urban areas, roadside settlements and rural villages in Mwanza Region, Tanzania. AIDS. 1992 Dec;6(12):1521–1528. [PubMed]
  • Barongo LR, Borgdorff MW, Newell JN, Senkoro KP, Klokke AH, Changalucha J, Deville W, Velema JP, Coutinho RA, Gabone RM. Intake of a cohort study of urban factory workers in northwest Tanzania. Risk factors for HIV-1 infection. Trop Geogr Med. 1994;46(3):157–162. [PubMed]
  • Borgdorff MW, Barongo LR, Newell JN, Senkoro KP, Devillé W, Velema JP, Gabone RM. Sexual partner change and condom use among urban factory workers in northwest Tanzania. Genitourin Med. 1994 Dec;70(6):378–383. [PMC free article] [PubMed]
  • Leroy V, Van de Perre P, Lepage P, Saba J, Nsengumuremyi F, Simonon A, Karita E, Msellati P, Salamon R, Dabis F. Seroincidence of HIV-1 infection in African women of reproductive age: a prospective cohort study in Kigali, Rwanda, 1988-1992. AIDS. 1994 Jul;8(7):983–986. [PubMed]
  • Ahmed HJ, Omar K, Adan SY, Guled AM, Grillner L, Bygdeman S. Syphilis and human immunodeficiency virus seroconversion during a 6-month follow-up of female prostitutes in Mogadishu, Somalia. Int J STD AIDS. 1991 Mar-Apr;2(2):119–123. [PubMed]
  • Kanki PJ, Travers KU, MBoup S, Hsieh CC, Marlink RG, Gueye-NDiaye A, Siby T, Thior I, Hernandez-Avila M, Sankalé JL, et al. Slower heterosexual spread of HIV-2 than HIV-1. Lancet. 1994 Apr 16;343(8903):943–946. [PubMed]
  • Stoneburner RL, Des Jarlais DC, Benezra D, Gorelkin L, Sotheran JL, Friedman SR, Schultz S, Marmor M, Mildvan D, Maslansky R. A larger spectrum of severe HIV-1--related disease in intravenous drug users in New York City. Science. 1988 Nov 11;242(4880):916–919. [PubMed]
  • Selwyn PA, Alcabes P, Hartel D, Buono D, Schoenbaum EE, Klein RS, Davenny K, Friedland GH. Clinical manifestations and predictors of disease progression in drug users with human immunodeficiency virus infection. N Engl J Med. 1992 Dec 10;327(24):1697–1703. [PubMed]
  • Lucas SB, Hounnou A, Peacock C, Beaumel A, Djomand G, N'Gbichi JM, Yeboue K, Hondé M, Diomande M, Giordano C, et al. The mortality and pathology of HIV infection in a west African city. AIDS. 1993 Dec;7(12):1569–1579. [PubMed]

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