PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of cjvetresCVMACanadian Journal of Veterinary ResearchSee also Canadian Journal of Comparative MedicineJournal Web siteHow to Submit
 
Can J Vet Res. 1997 April; 61(2): 128–133.
PMCID: PMC1189389

An inherited platelet function defect in a Simmental crossbred herd.

Abstract

An inherited bleeding disorder, resembling Simmental hereditary thrombopathy (SHT), has been identified in a Simmental crossbred herd. In an affected bull calf, initially evaluated because of excessive bleeding from a vaccination site, the platelet aggregation response to the agonist, adenosine-diphosphate (ADP) was essentially absent and the aggregation response to platelet activating factor (PAF16) was reduced by at least 70%. The initial laboratory assessment of platelet function in the dam and sire yielded results which were within normal limits. The sire was not available for further testing. The dam, also a daughter of this sire, was subsequently shown to have a partially reduced aggregation response to ADP. Of 18 other offspring of the sire evaluated, 6 were also identified as having a partially impaired aggregation response. The maximum aggregation response to ADP and PAF16 in these 6 calves was approximately 50% of the level exhibited by unaffected animals. In contrast, the coagulation profiles were normal for all animals except for a heifer calf which also exhibited a partially impaired aggregation response. The plasma level of the coagulation protein, factor XI, was reduced in this heifer calf which suffered a fatal hemorrhage following dehorning. This report appears to be the 1st to have identified animals putatively heterozygous for SHT on the basis of the in vitro platelet aggregation response to ADP.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.1M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Searcy GP, Petrie L. Clinical and laboratory findings of a bleeding disorder in Simmental cattle. Can Vet J. 1990 Feb;31(2):101–103. [PMC free article] [PubMed]
  • Steficek BA, Thomas JS, Baker JC, Bell TG. Hemorrhagic diathesis associated with a hereditary platelet disorder in Simmental cattle. J Vet Diagn Invest. 1993 Apr;5(2):202–207. [PubMed]
  • Sullivan PS, Grubbs ST, Olchowy TW, Andrews FM, White JG, Catalfamo JL, Dodd PA, McDonald TP. Bleeding diathesis associated with variant von Willebrand factor in a Simmental calf. J Am Vet Med Assoc. 1994 Dec 15;205(12):1763–1766. [PubMed]
  • Navarre CB, Kasari TR, Green RA. Platelet function defect in a 5-day-old Simmental calf. J Vet Intern Med. 1995 Jul-Aug;9(4):283–285. [PubMed]
  • Gentry PA. The mammalian blood platelet: its role in haemostasis, inflammation and tissue repair. J Comp Pathol. 1992 Oct;107(3):243–270. [PubMed]
  • Meyers KM. Pathobiology of animal platelets. Adv Vet Sci Comp Med. 1985;30:131–165. [PubMed]
  • White JG. The secretory pathway of bovine platelets. Blood. 1987 Mar;69(3):878–885. [PubMed]
  • Grouse LH, Rao GH, Weiss DJ, Perman V, White JG. Surface-activated bovine platelets do not spread, they unfold. Am J Pathol. 1990 Feb;136(2):399–408. [PubMed]
  • Searcy GP, Sheridan D, Dobson KA. Preliminary studies of a platelet function disorder in Simmental cattle. Can J Vet Res. 1990 Jun;54(3):394–396. [PMC free article] [PubMed]
  • Steficek BA, Thomas JS, McConnell MF, Bell TG. A primary platelet disorder of consanguineous simmental cattle. Thromb Res. 1993 Oct 15;72(2):145–153. [PubMed]
  • Searcy GP, Frojmovic MM, McNicol A, Robertson C, Wong T, Gerrard JM. Platelets from bleeding Simmental cattle mobilize calcium, phosphorylate myosin light chain and bind normal numbers of fibrinogen molecules but have abnormal cytoskeletal assembly and aggregation in response to ADP. Thromb Haemost. 1994 Feb;71(2):240–246. [PubMed]
  • Bondy GS, Gentry PA. Characterization of the normal bovine platelet aggregation response. Comp Biochem Physiol C. 1989;92(1):67–72. [PubMed]
  • Gentry PA, Ross ML. Failure of Routine Coagulation Screening Tests to Detect Heterozygous State of Bovine Factor XI Deficiency. Vet Clin Pathol. 1986;15(3):12–16. [PubMed]
  • Yamada M, Gentry PA. The hemostatic profile of equine ovarian follicular fluid. Thromb Res. 1995 Jan 1;77(1):45–54. [PubMed]
  • Gentry PA, Ross ML, Hayatgheybi H. Competency of blood coagulation in the newborn calf. Res Vet Sci. 1994 Nov;57(3):336–342. [PubMed]
  • Gentry PA, Ross ML. Coagulation factor XI deficiency in Holstein cattle: expression and distribution of factor XI activity. Can J Vet Res. 1994 Oct;58(4):242–247. [PMC free article] [PubMed]
  • Broze GJ., Jr The role of tissue factor pathway inhibitor in a revised coagulation cascade. Semin Hematol. 1992 Jul;29(3):159–169. [PubMed]

Articles from Canadian Journal of Veterinary Research are provided here courtesy of Canadian Veterinary Medical Association