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Logo of jpnSubmit a ManuscriptEmail AlertsAbout JPNJournal of Psychiatry and Neuroscience
J Psychiatry Neurosci. 1991 March; 16(1): 12–18.
PMCID: PMC1188282

Negative symptoms: psychopathological models.


The psychopathological manifestations of schizophrenia have been broadly divided into positive and negative symptom groups. Even though there is no definitive consensus, psychomotor agitation, motor excitement, hallucinations, delusions and thought disorder constitute positive and psychomotor retardation, amotivation, apathy and decreased emotional expression are grouped into negative symptoms. The negative symptoms have been reported to appear late in the course of the illness and resistant to treatment with neuroleptics. While these claims have not been substantiated, the current interest on negative symptoms is related to the fact that many nonfunctioning institutionalized as well as ambulatory schizophrenics manifest negative symptoms. As chronic psychiatric beds have become scarce, many patients with negative symptoms who were harbored in the chronic mental hospitals have been released to the community care and some of these patients live on the streets. Thus their visibility has challenged psychiatry to focus its efforts on the etiology and treatment of negative symptoms.

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Selected References

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  • Allen HA. Do positive symptom and negative symptom subtypes of schizophrenia show qualitative differences in language production? Psychol Med. 1983 Nov;13(4):787–797. [PubMed]
  • Alpert M, Friedhoff AJ. An un-dopamine hypothesis of schizophrenia. Schizophr Bull. 1980;6(3):387–389. [PubMed]
  • Andreasen NC. Negative symptoms in schizophrenia. Definition and reliability. Arch Gen Psychiatry. 1982 Jul;39(7):784–788. [PubMed]
  • Andreasen NC, Olsen S. Negative v positive schizophrenia. Definition and validation. Arch Gen Psychiatry. 1982 Jul;39(7):789–794. [PubMed]
  • Andreasen NC, Olsen SA, Dennert JW, Smith MR. Ventricular enlargement in schizophrenia: relationship to positive and negative symptoms. Am J Psychiatry. 1982 Mar;139(3):297–302. [PubMed]
  • Ashcroft GW, Blackwood GW, Besson JA, Palomo T, Waring HL. Positive and negative schizophrenic symptoms and the role of dopamine. Br J Psychiatry. 1981 Mar;138:268–269. [PubMed]
  • Ax AF, Bamford JL, Beckett PG, Domino EF, Gottlieb JS. Autonomic response patterning of chronic schizophrenics. Psychosom Med. 1969 Sep-Oct;31(5):353–364. [PubMed]
  • Benes F, Sunderland P, Jones BD, LeMay M, Cohen BM, Lipinski JF. Normal ventricles in young schizophrenics. Br J Psychiatry. 1982 Jul;141:90–93. [PubMed]
  • Berman SA, Hayman LA, Hinck VC. Correlation of CT cerebral vascular territories with function: 3. Middle cerebral artery. AJR Am J Roentgenol. 1984 May;142(5):1035–1040. [PubMed]
  • Buchanan FH, Parton RV, Warren JW, Baker EP. Double blind trial of L-dopa in chronic schizophrenia. Aust N Z J Psychiatry. 1975 Dec;9(4):269–271. [PubMed]
  • Buchsbaum MS, DeLisi LE, Holcomb HH, Cappelletti J, King AC, Johnson J, Hazlett E, Dowling-Zimmerman S, Post RM, Morihisa J, et al. Anteroposterior gradients in cerebral glucose use in schizophrenia and affective disorders. Arch Gen Psychiatry. 1984 Dec;41(12):1159–1166. [PubMed]
  • Rosen WG, Mohs RC, Johns CA, Small NS, Kendler KS, Horvath TB, Davis KL. Positive and negative symptoms in schizophrenia. Psychiatry Res. 1984 Dec;13(4):277–284. [PubMed]
  • Carpenter WT, Jr, Heinrichs DW, Alphs LD. Treatment of negative symptoms. Schizophr Bull. 1985;11(3):440–452. [PubMed]
  • Carpenter WT, Jr, Strauss JS, Bartko JJ. Flexible system for the diagnosis of schizophrenia: report from the WHO International Pilot Study of Schizophrenia. Science. 1973 Dec 21;182(4118):1275–1278. [PubMed]
  • CASEY JF, BENNETT IF, LINDLEY CJ, HOLLISTER LE, GORDON MH, SPRINGER NN. Drug therapy in schizophrenia. A controlled study of the relative effectiveness of chlorpromazine, promazine, phenobarbital, and placebo. AMA Arch Gen Psychiatry. 1960 Feb;2:210–220. [PubMed]
  • Chouinard G, Jones BD. Schizophrenia as dopamine-deficiency disease. Lancet. 1978 Jul 8;2(8080):99–100. [PubMed]
  • Cornblatt BA, Lenzenweger MF, Dworkin RH, Erlenmeyer-Kimling L. Positive and negative schizophrenic symptoms, attention, and information processing. Schizophr Bull. 1985;11(3):397–408. [PubMed]
  • Cox SM, Ludwig AM. Neurological soft signs and psychopathology. I. Findings in schizophrenia. J Nerv Ment Dis. 1979 Mar;167(3):161–165. [PubMed]
  • Crow TJ. Positive and negative schizophrenic symptoms and the role of dopamine. Br J Psychiatry. 1980 Oct;137:383–386. [PubMed]
  • Donnelly EF, Weinberger DR, Waldman IN, Wyatt RJ. Cognitive impairment associated with morphological brain abnormalities on computed tomography in chronic schizophrenic patients. J Nerv Ment Dis. 1980 May;168(5):305–308. [PubMed]
  • Dworkin RH, Lenzenweger MF. Symptoms and the genetics of schizophrenia: implications for diagnosis. Am J Psychiatry. 1984 Dec;141(12):1541–1546. [PubMed]
  • Farkas T, Wolf AP, Jaeger J, Brodie JD, Christman DR, Fowler JS. Regional brain glucose metabolism in chronic schizophrenia. A positron emission transaxial tomographic study. Arch Gen Psychiatry. 1984 Mar;41(3):293–300. [PubMed]
  • Gerlach J, Lühdorf K. The effect of L-dopa on young patients with simple schizophrenia, treated with neuroleptic drugs: a double-blind cross-over trial with Madopar and placebo. Psychopharmacologia. 1975 Oct 14;44(1):105–110. [PubMed]
  • Purisch AD, Golden CJ, Hammeke TA. Discrimination of schizophrenic and brain-injured patients by a standardized version of Luria's neuropsychological tests. J Consult Clin Psychol. 1978 Dec;46(6):1266–1273. [PubMed]
  • Golden CJ, Moses JA, Jr, Zelazowski R, Graber B, Zatz LM, Horvath TB, Berger PA. Cerebral ventricular size and neuropsychological impairment in young chronic schizophrenics. Measurement by the standardized Luria-Nebraska Neuropsychological Battery. Arch Gen Psychiatry. 1980 Jun;37(6):619–623. [PubMed]
  • Gruenberg EM. The social breakdown syndrome--some origins. Am J Psychiatry. 1967 Jun;123(12):1481–1489. [PubMed]
  • HAUG JO. Pneumoencephalographic studies in mental disease. Acta Psychiatr Scand Suppl. 1962;38(165):1–104. [PubMed]
  • Huber G, Gross G, Schüttler R. A long-term follow-up study of schizophrenia: psychiatric course of illness and prognosis. Acta Psychiatr Scand. 1975 Jul;52(1):49–57. [PubMed]
  • Inanaga K, Inoue K, Tachibana H, Oshima M, Kotorii T. Effect of L-dopa in schizophrenia. Folia Psychiatr Neurol Jpn. 1972;26(2):145–157. [PubMed]
  • Ingvar DH, Franzén G. Abnormalities of cerebral blood flow distribution in patients with chronic schizophrenia. Acta Psychiatr Scand. 1974;50(4):425–462. [PubMed]
  • Jernigan TL, Zatz LM, Moses JA, Jr, Berger PA. Computed tomography in schizophrenics and normal volunteers. I. Fluid volume. Arch Gen Psychiatry. 1982 Jul;39(7):765–770. [PubMed]
  • Johnstone EC, Crow TJ, Frith CD, Husband J, Kreel L. Cerebral ventricular size and cognitive impairment in chronic schizophrenia. Lancet. 1976 Oct 30;2(7992):924–926. [PubMed]
  • Kay SR, Singh MM. Cognitive abnormality in schizophrenia: a dual-process model. Biol Psychiatry. 1979 Feb;14(1):155–176. [PubMed]
  • Kolakowska T, Williams AO, Ardern M, Reveley MA, Jambor K, Gelder MG, Mandelbrote BM. Schizophrenia with good and poor outcome. I: Early clinical features, response to neuroleptics and signs of organic dysfunction. Br J Psychiatry. 1985 Mar;146:229–239. [PubMed]
  • Kolakowska T, Williams AO, Jambor K, Ardern M. Schizophrenia with good and poor outcome. III: Neurological 'soft' signs, cognitive impairment and their clinical significance. Br J Psychiatry. 1985 Apr;146:348–357. [PubMed]
  • Krieger DT. Brain peptides: what, where, and why? Science. 1983 Dec 2;222(4627):975–985. [PubMed]
  • Lewine RJ, Meltzer HY. Negative symptoms and platelet monoamine oxidase activity in male schizophrenic patients. Psychiatry Res. 1984 Jun;12(2):99–109. [PubMed]
  • Lindenmayer JP, Kay SR, Opler L. Positive and negative subtypes in acute schizophrenia. Compr Psychiatry. 1984 Jul-Aug;25(4):455–464. [PubMed]
  • Manschreck TC. Psychopathology of motor behavior in schizophrenia. Prog Exp Pers Res. 1983;12:53–99. [PubMed]
  • Mackay AV. Positive and negative schizophrenic symptoms and the role of dopamine. Br J Psychiatry. 1980 Oct;137:379–383. [PubMed]
  • Opler LA, Kay SR, Rosado V, Lindenmayer JP. Positive and negative syndromes in chronic schizophrenic inpatients. J Nerv Ment Dis. 1984 Jun;172(6):317–325. [PubMed]
  • Pearlson GD, Veroff AE. Computerised tomographic scan changes in manic-depressive illness. Lancet. 1981 Aug 29;2(8244):470–470. [PubMed]
  • Rosen WG, Mohs RC, Johns CA, Small NS, Kendler KS, Horvath TB, Davis KL. Positive and negative symptoms in schizophrenia. Psychiatry Res. 1984 Dec;13(4):277–284. [PubMed]
  • Scott ML, Golden CJ, Ruedrich SL, Bishop RJ. Ventricular enlargement in major depression. Psychiatry Res. 1983 Feb;8(2):91–93. [PubMed]
  • Sommers AA. "Negative symptoms": conceptual and methodological problems. Schizophr Bull. 1985;11(3):364–379. [PubMed]
  • Standish-Barry HM, Bouras N, Bridges PK, Bartlett JR. Pneumo-encephalographic and computerized axial tomography scan changes in affective disorder. Br J Psychiatry. 1982 Dec;141:614–617. [PubMed]
  • Van Putten T, May RP. "Akinetic depression" in schizophrenia. Arch Gen Psychiatry. 1978 Sep;35(9):1101–1107. [PubMed]
  • Weinberger DR, Bigelow LB, Kleinman JE, Klein ST, Rosenblatt JE, Wyatt RJ. Cerebral ventricular enlargement in chronic schizophrenia. An association with poor response to treatment. Arch Gen Psychiatry. 1980 Jan;37(1):11–13. [PubMed]
  • Weinberger DR, Bigelow LB, Kleinman JE, Klein ST, Rosenblatt JE, Wyatt RJ. Cerebral ventricular enlargement in chronic schizophrenia. An association with poor response to treatment. Arch Gen Psychiatry. 1980 Jan;37(1):11–13. [PubMed]
  • Weinberger DR, Torrey EF, Neophytides AN, Wyatt RJ. Lateral cerebral ventricular enlargement in chronic schizophrenia. Arch Gen Psychiatry. 1979 Jul;36(7):735–739. [PubMed]
  • Williams AO, Reveley MA, Kolakowska T, Ardern M, Mandelbrote BM. Schizophrenia with good and poor outcome. II: Cerebral ventricular size and its clinical significance. Br J Psychiatry. 1985 Mar;146:239–246. [PubMed]

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