Mol Pathol. 2003 April; 56(2): 127–128.
© 2003, Journal of Clinical Pathology
Proposal for a unified CCN nomenclature
1Department of Surgery, Ohio State University, Colombus, Ohio 43205, USA
2Pathology H04.312, University Hospital Utrecht, Utrecht, The Netherlands
3Molecular Pahology, Graduate School of Tokyo Medical and Dental University, Yushima, Tokyo,113–8549 Japan
4Department of Pharmacology, University of Illinois, Chicago, IL 60612, USA
5Department of Molecular Genetics, University of Illinois, Chicago, IL 60607, USA
6Department of Molecular, Cell and Developmental Biology, UCLA, Los Angeles, CA 90095, USA
7Department of Anatomy, University of British Columbia, Vancouver V6T 1Z3, Canada
8Laboratoire d’Oncologie Virale et Moléculaire, Université Paris 7-D, 75005 Paris, France
9Baxter Healthcare Renal Division, Magaw Park, IL 60085, USA
10Department of Biochemistry and Molecular Dentistry Okayama University Graduate School of Medicine and Dentistry, Okayama, 700–8525, Japan
11Department of Pediatric Laboratory Medicine, Hospital for Sick Children, Toronto M5G 1XB, Canada
Accepted January 31, 2003.
A proposal is put forth to unify the nomenclature of the CCN family of secreted, cysteine rich regulatory proteins. In the order of their description in the literature, CCN1 (CYR61), CCN2 (CTGF), CCN3 (NOV), CCN4 (WISP-1), CCN5 (WISP-2), and CCN6 (WISP-3) constitute a family of matricellular proteins that regulate cell adhesion, migration, proliferation, survival, and differentiation, at least in part through integrin mediated mechanisms. This proposal is endorsed by the International CCN Society and will serve to eliminate confusion from the multiple names that have been given to these molecules.
Keywords: CCN, CYR61, CTGF, NOVH, WISP1, WISP2, WISP3