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J Clin Pathol. 1981 February; 34(2): 145–150.
PMCID: PMC1146440

Comparative studies of spermatogenesis in fertile and subfertile men.

Abstract

Testicular biopsy specimens from 16 fertile and 10 subfertile men with normal male karyotype were studied quantitatively to provide histological and cytogenetic data for a basis of reference in assessing abnormalities of spermatogenesis. Histological studies included estimation of the proportion and activity of germinal epithelium and an assessment of tubular morphology. In cytogenetic preparations, counts were made of cells at different stages of meiosis. Studies of cells at diakinesis included chiasma counts and percentage of cells with dissociated sex chromosomes. One fertile and six subfertile men showed decreased germinal activity; the six subfertile men also had decreased MII/MI ratios. Other findings were similar in the two groups.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Coppleson LW, Factor RM, Strum SB, Graff PW, Rappaport H. Observer disagreement in the classification and histology of Hodgkin's disease. J Natl Cancer Inst. 1970 Oct;45(4):731–740. [PubMed]
  • Johnsen SG. Testicular biopsy score count--a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males. Hormones. 1970;1(1):2–25. [PubMed]
  • Skakkebaek NE, Heller CG. Quantification of human seminiferous epithelium. I. Histological studies in twenty-one fertile men with normal chromosome complements. J Reprod Fertil. 1973 Mar;32(3):379–389. [PubMed]
  • Skakkebaek NE, Hammen R, Philip J, Rebbe H. Quantification of human seminiferous epithelium. 3. Histological studies in 44 infertile men with normal chromosome complements. Acta Pathol Microbiol Scand A. 1973 Mar;81(2):97–111. [PubMed]
  • Averback P, Wight DG. Seminiferous tubule hypercurvature: A newly recognised common syndrome of human male infertility. Lancet. 1979 Jan 27;1(8109):181–183. [PubMed]
  • Tulloch WS, Newsam JE. Studies on human meiotic chromosomes from testicular tissue. Lancet. 1966 Mar 26;1(7439):679–682. [PubMed]
  • Skakkebaek NE, Bryant JI, Philip J. Studies on meiotic chromosomes in infertile men and controls with normak karyotypes. J Reprod Fertil. 1973 Oct;35(1):23–36. [PubMed]
  • McDermott A. The frequency and distribution of chiasmata in man. Ann Hum Genet. 1973 Jul;37(1):13–20. [PubMed]
  • EVANS EP, BRECKON G, FORD CE. AN AIR-DRYING METHOD FOR MEIOTIC PREPARATIONS FROM MAMMALIAN TESTES. Cytogenetics. 1964;3:289–294. [PubMed]
  • Chandley AC, Fletcher JM. Centromere staining at meiosis in man. Humangenetik. 1973 May 25;18(3):247–252. [PubMed]
  • Chandley AC, Maclean N, Edmond P, Fletcher J, Watson GS. Cytogenetics and infertility in man. II. Testicular histology and meiosis. Ann Hum Genet. 1976 Nov;40(2):165–176. [PubMed]

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