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J Clin Pathol. 1989 July; 42(7): 745–748.
PMCID: PMC1142027

Comparative study of iliac crest and proximal femur histomorphometry in normal patients.


The relation between the bone histomorphometric profile of the iliac crest and regions of the proximal femur was investigated. In the proximal femur four blocks were selected, representing the subchondral principal compressive (SPC) and tensile (SPT) regions, the zone near the medial cortex in the principal compressive region (MPC), and the zone medial to the greater trochanter (MGT). Undecalcified tissue sections stained by the von Kossa silver method and counterstained with haematoxylin and eosin were used for quantitation. The SPT region was most representative of the iliac bone profile, in particular the structural parameters of mineralised bone, trabecular thickness, and trabecular spacing and resorption surface. Most parameters in the regions studied showed inconsistent and variable results when compared with those of the iliac crest. There was only a weak association, therefore, between the histomorphometric parameters of the iliac crest and the proximal femur despite the appeal of the use of the iliac biopsy specimen as a simple clinical test.

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Selected References

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  • Pugh JW, Radin EL, Rose RM. Quantitative studies of human subchondral cancellous bone. Its relationship to the state of its overlying cartilage. J Bone Joint Surg Am. 1974 Mar;56(2):313–321. [PubMed]
  • Hvid I. Mechanical strength of trabecular bone at the knee. Dan Med Bull. 1988 Aug;35(4):345–365. [PubMed]
  • Saito M, Saito S, Ohzono K, Ono K. The osteoblastic response to osteoarthritis of the hip. Its influence on the long-term results of arthroplasty. J Bone Joint Surg Br. 1987 Nov;69(5):746–751. [PubMed]
  • McCarthy P. Hip fractures in elderly women. Med J Aust. 1985 Oct 14;143(8):372–372. [PubMed]
  • Wicks M, Garrett R, Vernon-Roberts B, Fazzalari N. Absence of metabolic bone disease in the proximal femur in patients with fracture of the femoral neck. J Bone Joint Surg Br. 1982;64(3):319–322. [PubMed]
  • Byers PD, Contepomi CA, Farkas TA. A post mortem study of the hip joint. Including the prevalence of the features of the right side. Ann Rheum Dis. 1970 Jan;29(1):15–31. [PMC free article] [PubMed]
  • Parfitt AM, Drezner MK, Glorieux FH, Kanis JA, Malluche H, Meunier PJ, Ott SM, Recker RR. Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res. 1987 Dec;2(6):595–610. [PubMed]
  • Merz WA, Schenk RK. Quantitative structural analysis of human cancellous bone. Acta Anat (Basel) 1970;75(1):54–66. [PubMed]
  • Fazzalari NL, Vernon-Roberts B, Darracott J. Osteoarthritis of the hip. Possible protective and causative roles of trabecular microfractures in the head of the femur. Clin Orthop Relat Res. 1987 Mar;(216):224–233. [PubMed]
  • Solomon L, Schnitzler CM, Browett JP. Osteoarthritis of the hip: the patient behind the disease. Ann Rheum Dis. 1982 Apr;41(2):118–125. [PMC free article] [PubMed]

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