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J Clin Pathol. 1987 July; 40(7): 798–802.
PMCID: PMC1141101

Accumulation of ceroid in smooth muscle indicates severe malabsorption and vitamin E deficiency.


Four patients had accumulation of ceroid in smooth muscle (lipofuscinosis), which indicated severe or uncontrolled malabsorption, with confirmed vitamin E deficiency in three cases. The distribution of the pigment was systematic, and there seemed to be an association between malabsorption syndrome and vitamin E deficiency. Vitamin E supplementation seems to be indicated in such patients, and it is suggested that studies of smooth muscle function should be made in cases of heavy accumulation of ceroid.

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Selected References

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