PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of jcinvestThe Journal of Clinical Investigation
 
J Clin Invest. 1983 July; 72(1): 96–101.
PMCID: PMC1129164

Gluten-sensitive enteropathy. Immunoglobulin G heavy-chain (Gm) allotypes and the immune response to wheat gliadin.

Abstract

Anti-gliadin antibody was measured by radioimmunoassay in 30 Caucasians with gluten-sensitive enteropathy (GSE). 22 GSE patients maintained on a gluten-free diet for 1.5 to 20 yr (mean duration 76 mo) had elevated serum concentrations of IgG antigliadin antibody. Among GSE patients on a gluten-free diet, antigliadin antibody was seen only in those having the chromosome 14-encoded IgG immunoglobulin heavy chain allotype marker G2m(n). IgG antigliadin antibody was found in GSE patients with G2m(n) regardless of whether the HLA-B8 and/or -DR3 major histocompatibility complex antigens that occur frequently in GSE were present. No patient lacking G2m(n) had significant levels of antigliadin antibody. The association between antigliadin antibody and the immunoglobulin heavy chain allotype marker G2m(n) in GSE patients likely reflects the presence of Gmn-linked variable region genes or Gmn-linked genes that regulate variable region gene expression.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (986K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Holmes GK, Asquith P, Stokes PL, Cooke WT. Cellular infiltrate of jejunal biopsies in adult coeliac disease in relation to gluten withdrawal. Gut. 1974 Apr;15(4):278–283. [PMC free article] [PubMed]
  • Lancaster-Smith M, Kumar P, Marks R, Clark ML, Dawson AM. Jejunal mucosal immunoglobulin-containing cells and jejunal fluid immunoglobulins in adult coeliac disease and dermatitis herpetiformis. Gut. 1974 May;15(5):371–376. [PMC free article] [PubMed]
  • Ferguson A, MacDonald TT, McClure JP, Holden RJ. Cell-mediated immunity to gliadin within the small-intestinal mucosa in coeliac disease. Lancet. 1975 Apr 19;1(7912):895–897. [PubMed]
  • Falchuk ZM. Update on gluten-sensitive enteropathy. Am J Med. 1979 Dec;67(6):1085–1096. [PubMed]
  • Falchuk ZM, Rogentine GN, Strober W. Predominance of histocompatibility antigen HL-A8 in patients with gluten-sensitive enteropathy. J Clin Invest. 1972 Jun;51(6):1602–1605. [PMC free article] [PubMed]
  • Stokes PL, Asquith P, Holmes GK, Mackintosh P, Cooke WT. Histocompatibility antigens associated with adult coeliac disease. Lancet. 1972 Jul 22;2(7769):162–164. [PubMed]
  • Ek J, Albrechtsen D, Solheim BG, Thorsby E. Strong association between the HLA-Dw3-related B cell alloantigen -DRw3 and coeliac disease. Scand J Gastroenterol. 1978;13(2):229–233. [PubMed]
  • Albert ED, Harms K, Wank R, Steinbauer-Rosenthal I, Scholz S. Segregation analysis of HL-A antigens and haplotypes in 50 families of patients with coeliac disease. Transplant Proc. 1973 Dec;5(4):1785–1789. [PubMed]
  • Rood JJ, Hooff JP, Keuning JJ. Disease predisposition, immune responsiveness and the fine structure of the HL-A supergene. A need for a reappraisal. Transplant Rev. 1975;22:75–104. [PubMed]
  • Mann DL, Katz SI, Nelson DL, Abelson LD. Specific B-cell antigens associated with gluten-sensitive enteropathy and dermatitis herpetiformis. Lancet. 1976 Jan 17;1(7951):110–111. [PubMed]
  • Peña AS, Mann DL, Hague NE, Heck JA, van Leeuwen HA, van Rood JJ, Strober W. Genetic basis of gluten-sentitive enteropathy. Gastroenterology. 1978 Aug;75(2):230–235. [PubMed]
  • Eterman KP, Feltkamp TE. Antibodies to gluten and reticulin in gastrointestinal diseases. Clin Exp Immunol. 1978 Jan;31(1):92–99. [PubMed]
  • Stern M, Fischer K, Grüttner R. Immunofluorescent serum gliadin antibodies in children with coeliac disease and various malabsorptive disorders. II. Specificity of Gliadin antibodies: immunoglobulin classes, immunogenic properties of wheat protein fractions, and pathogenic significance of food antibodies in coeliac disease. Eur J Pediatr. 1979 Mar 1;130(3):165–172. [PubMed]
  • Signer E, Bürgin-Wolff A, Berger R, Birbaumer A, Just M. Antibodies to gliadin as a screening test for coeliac disease. A prospective study. Helv Paediatr Acta. 1979 Feb;34(1):41–52. [PubMed]
  • Unsworth DJ, Manuel PD, Walker-Smith JA, Campbell CA, Johnson GD, Holborow EJ. New immunofluorescent blood test for gluten sensitivity. Arch Dis Child. 1981 Nov;56(11):864–868. [PMC free article] [PubMed]
  • Kagnoff MF. Two genetic loci control the murine immune response to A-gliadin, a wheat protein that activates coeliac sprue. Nature. 1982 Mar 11;296(5853):158–160. [PubMed]
  • Kagnoff MF, Weiss JB, Brown RJ, Lee T, Schanfield MS. Immunoglobulin allotype markers in gluten-sensitive enteropathy. Lancet. 1983 Apr 30;1(8331):952–953. [PubMed]
  • Kagnoff MF, Austin RK, Johnson HC, Bernardin JE, Dietler MD, Kasarda DD. Celiac sprue: correlation with murine T cell responses to wheat gliadin components. J Immunol. 1982 Dec;129(6):2693–2697. [PubMed]
  • Trefts PE, Kagnoff MF. Gluten-sensitive enteropathy. I. The T-dependent anti-A-gliadin antibody response maps to the murine major histocompatibility locus. J Immunol. 1981 Jun;126(6):2249–2252. [PubMed]
  • Kenrick KG, Walker-Smith JA. Immunoglobulins and dietary protein antibodies in childhood coeliac disease. Gut. 1970 Aug;11(8):635–640. [PMC free article] [PubMed]
  • KIVEL RM, KEARNS DH, LIEBOWITZ D. SIGNIFICANCE OF ANTIBODIES TO DIETARY PROTEINS IN THE SERUMS OF PATIENTS WITH NONTROPICAL SPRUE. N Engl J Med. 1964 Oct 8;271:769–772. [PubMed]
  • ALARCON SEGOVIA D, HERSKOVIC T, WAKIM KG, GREEN PA, SCUDAMORE HH. PRESENCE OF CIRCULATING ANTIBODIES TO GLUTEN AND MILK FRACTIONS IN PATIENTS WITH NONTROPICAL SPRUE. Am J Med. 1964 Apr;36:485–499. [PubMed]
  • TAYLOR KB, TRUELOVE SC, WRIGHT R. SEROLOGIC REACTIONS TO GLUTEN AND COW'S MILK PROTEINS IN GASTROINTESTINAL DISEASE. Gastroenterology. 1964 Feb;46:99–108. [PubMed]
  • Jonsson J, Schilling W. Some characteristics of immunofluorescence tests for antibodies against gluten, using wheat grain sections or gliadin coated sepharose beads. Acta Pathol Microbiol Scand C. 1981 Aug;89(4):253–262. [PubMed]
  • Shiner M, Ballard J. Antigen-antibody reactions in jejunal mucosa in childhood coeliac disease after gluten challenge. Lancet. 1972 Jun 3;1(7762):1202–1205. [PubMed]
  • Scott BB, Scott DG, Losowsky MS. Jejunal mucosal immunoglobulins and complement in untreated coeliac disease. J Pathol. 1977 Apr;121(4):219–223. [PubMed]
  • Hahn WV, Kagnoff MF, Hatlen LH. Immune responses in human colon cancer. II. Cytotoxic antibody detected in patients' sera. J Natl Cancer Inst. 1978 Apr;60(4):779–784. [PubMed]
  • Unsworth DJ, Johnson GD, Haffenden G, Fry L, Holborow EJ. Binding of wheat gliadin in vitro to reticulum in normal and dermatitis herpetiformis skin. J Invest Dermatol. 1981 Feb;76(2):88–93. [PubMed]
  • RUBIN W, FAUCI AS, MARVIN SF, SLEISENGER MH, JEFRIES GH. IMMUNOFLUORESCENT STUDIES IN ADULT CELIAC DISEASE. J Clin Invest. 1965 Mar;44:475–485. [PMC free article] [PubMed]
  • Mackay IR, Tait BD. HLA associations with autoimmune-type chronic active hepatitis: identification of B8-DRw3 haplotype by family studies. Gastroenterology. 1980 Jul;79(1):95–98. [PubMed]
  • Lawley TJ, Hall RP, Fauci AS, Katz SI, Hamburger MI, Frank MM. Defective Fc-receptor functions associated with the HLA-B8/DRw3 haplotype: studies in patients with dermatitis herpetiformis and normal subjects. N Engl J Med. 1981 Jan 22;304(4):185–192. [PubMed]
  • Nakao Y, Matsumoto H, Miyazaki T, Mizuno N, Arima N, Wakisaka A, Okimoto K, Akazawa Y, Tsuji K, Fujita T. IgG heavy-chain (Gm) allotypes and immune response to insulin in insulin-requiring diabetes mellitus. N Engl J Med. 1981 Feb 12;304(7):407–409. [PubMed]
  • Whittingham S, Mathews JD, Schanfield MS, Tait BD, Mackay IR. Interaction of HLA and Gm in autoimmune chronic active hepatitis. Clin Exp Immunol. 1981 Jan;43(1):80–86. [PubMed]
  • Nakao Y, Matsumoto H, Miyazaki T, Nishitani H, Ota K, Fujita T, Tsuji K. Gm allotypes in myasthenia gravis. Lancet. 1980 Mar 29;1(8170):677–680. [PubMed]
  • Uno H, Sasazuki T, Tamai H, Matsumoto H. Two major genes, linked to HLA and Gm, control susceptibility to Graves' disease. Nature. 1981 Aug 20;292(5825):768–770. [PubMed]

Articles from The Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation