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Occup Environ Med. 1994 May; 51(5): 302–307.
PMCID: PMC1127974

A case-control study of chronic neuropsychiatric disease and organic solvent exposure in automobile assembly plant workers.


A case-control study of chronic neurological and psychiatric disease and occupational exposure to solvents was carried out in eight automobile assembly plants. Cases included 299 subjects who were granted medical disability retirement in 1980-8. Two control groups were selected, the first from those granted retirement in the same period because of medical disability from causes unrelated to solvent exposure. The second included hourly employees from the plant population. In these facilities, solvent exposures tended to be short term and low level, although common: the average duration of exposure was 2.3 years; about 41% experienced at least one day of exposure. Of those exposed, 46% had less than one year of exposure. Results for all psychiatric disease combined (273 cases) suggested that cases had lower exposures than either control group, regardless of how exposure was expressed. Results could not be explained by conventional confounding exposures or characteristics or by usual manifestations of the healthy worker effect. By contrast, chronic neurological disease, and multiple sclerosis in particular, seemed to be associated with exposure, although few cases were identified and observed increases in risk were not statistically significant.

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Selected References

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  • Axelson O, Hane M, Hogstedt C. A case-referent study on neuropsychiatric disorders among workers exposed to solvents. Scand J Work Environ Health. 1976 Mar;2(1):14–20. [PubMed]
  • Brackbill RM, Maizlish N, Fischbach T. Risk of neuropsychiatric disability among painters in the United States. Scand J Work Environ Health. 1990 Jun;16(3):182–188. [PubMed]
  • Gubéran E, Usel M, Raymond L, Tissot R, Sweetnam PM. Disability, mortality, and incidence of cancer among Geneva painters and electricians: a historical prospective study. Br J Ind Med. 1989 Jan;46(1):16–23. [PMC free article] [PubMed]
  • Hogstedt C, Axelson O. Long-term health effects of industrial solvents--a critical review of the epidemiological research. Med Lav. 1986 Jan-Feb;77(1):11–22. [PubMed]
  • Lindström K, Riihimäki H, Hänninen K. Occupational solvent exposure and neuropsychiatric disorders. Scand J Work Environ Health. 1984 Oct;10(5):321–323. [PubMed]
  • Mikkelsen S. A cohort study of disability pension and death among painters with special regard to disabling presenile dementia as an occupational disease. Scand J Soc Med Suppl. 1980;16:34–43. [PubMed]
  • Olsen J, Sabroe S. A case-reference study of neuropsychiatric disorders among workers exposed to solvents in the Danish wood and furniture industry. Scand J Soc Med Suppl. 1980;16:44–49. [PubMed]
  • Rasmussen H, Olsen J, Lauritsen J. Risk of encephalopathia among retired solvent-exposed workers. A case-control study among males applying for nursing home accommodation or other types of social support facilities. J Occup Med. 1985 Aug;27(8):561–566. [PubMed]
  • Riise T, Moen BE. A nested case-control study of disability pension among seamen, with special reference to neuropsychiatric disorders and exposure to solvents. Neuroepidemiology. 1990;9(2):88–94. [PubMed]
  • van Vliet C, Swaen GM, Volovics A, Slangen JJ, Meijers JM, de Boorder T, Sturmans F. Exposure-outcome relationships between organic solvent exposure and neuropsychiatric disorders: results from a Dutch case-control study. Am J Ind Med. 1989;16(6):707–718. [PubMed]
  • van Vliet C, Swaen GM, Volovics A, Tweehuysen M, Meijers JM, de Boorder T, Sturmans F. Neuropsychiatric disorders among solvent-exposed workers. First results from a Dutch case-control study. Int Arch Occup Environ Health. 1990;62(2):127–132. [PubMed]
  • Mikkelsen S, Jørgensen M, Browne E, Gyldensted C. Mixed solvent exposure and organic brain damage. A study of painters. Acta Neurol Scand Suppl. 1988;118:1–143. [PubMed]
  • DEFALQUE RJ. Pharmacology and toxicology of trichloroethylene. A critical review of the literature. Clin Pharmacol Ther. 1961 Sep-Oct;2:665–688. [PubMed]
  • Feldman RG, Mayer RM, Taub A. Evidence for peripheral neurotoxic effect of trichloroethylene. Neurology. 1970 Jun;20(6):599–606. [PubMed]
  • Poser CM, Paty DW, Scheinberg L, McDonald WI, Davis FA, Ebers GC, Johnson KP, Sibley WA, Silberberg DH, Tourtellotte WW. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol. 1983 Mar;13(3):227–231. [PubMed]
  • Henzi H. Chronic methanol poisoning with the clinical and pathologic-anatomical features of multiple sclerosis. Med Hypotheses. 1984 Jan;13(1):63–75. [PubMed]
  • Noseworthy JH, Rice GP. Trichlorethylene poisoning mimicking multiple sclerosis. Can J Neurol Sci. 1988 Feb;15(1):87–88. [PubMed]
  • Amaducci L, Arfaioli C, Inzitari D, Marchi M. Multiple sclerosis among shoe and leather workers: an epidemiological survey in Florence. Acta Neurol Scand. 1982 Feb;65(2):94–103. [PubMed]
  • Flodin U, Söderfeldt B, Noorlind-Brage H, Fredriksson M, Axelson O. Multiple sclerosis, solvents, and pets. A case-referent study. Arch Neurol. 1988 Jun;45(6):620–623. [PubMed]
  • Juntunen J, Kinnunen E, Antti-Poika M, Koskenvuo M. Multiple sclerosis and occupational exposure to chemicals: a co-twin control study of a nationwide series of twins. Br J Ind Med. 1989 Jun;46(6):417–419. [PMC free article] [PubMed]
  • Souberbielle BE, Martin-Mondiere C, O'Brien ME, Carydakis C, Cesaro P, Degos JD. A case-control epidemiological study of MS in the Paris area with particular reference to past disease history and profession. Acta Neurol Scand. 1990 Nov;82(5):303–310. [PubMed]
  • Stein EC, Schiffer RB, Hall WJ, Young N. Multiple sclerosis and the workplace: report of an industry-based cluster. Neurology. 1987 Oct;37(10):1672–1677. [PubMed]

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