Search tips
Search criteria 


Logo of jnnpsycJournal of Neurology, Neurosurgery and PsychiatryVisit this articleSubmit a manuscriptReceive email alertsContact usBMJ
J Neurol Neurosurg Psychiatry. 1997 June; 62(6): 633–636.
PMCID: PMC1074151

SPECT, CT, and MRI in head injury: acute abnormalities followed up at six months.


Neuroimaging with single photon emission computed tomography (SPECT) using the cerebral blood flow tracer 99Tc(m)-HMPAO has been used to study acute functional alterations after head injury and residual abnormalities at six month follow up in 32 patients. Comparison has been made with anatomical abnormalities defined acutely with CT and on follow up with MRI. SPECT showed slightly more abnormalities than CT in the acute phase (49 regions of abnormally low tracer uptake on SPECT and 45 lesions on CT). Twenty two of the acute SPECT abnormalities were in normal regions on CT. At follow up MRI showed more abnormalities than SPECT (30 on SPECT and 48 on MRI). Ten of the SPECT deficits were in regions with normal MRI. Comparison of the intensity of late and early SPECT deficits showed that only four early deficits deteriorated whereas 28 improved. Only five of 27 lesions seen on both acute SPECT and CT resolved compared with 16 of 22 lesions seen on SPECT but not on CT. Regions of abnormally high tracer uptake were detected in the acute stage in five of the patients. No high focal uptake was evident on follow up. Ten patients with a residual SPECT abnormality and eight with residual MRI lesions were graded clinically in the upper band of good recovery.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (809K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Images in this article

Click on the image to see a larger version.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Roper SN, Mena I, King WA, Schweitzer J, Garrett K, Mehringer CM, McBride D. An analysis of cerebral blood flow in acute closed-head injury using technetium-99m-HMPAO SPECT and computed tomography. J Nucl Med. 1991 Sep;32(9):1684–1687. [PubMed]
  • Newton MR, Greenwood RJ, Britton KE, Charlesworth M, Nimmon CC, Carroll MJ, Dolke G. A study comparing SPECT with CT and MRI after closed head injury. J Neurol Neurosurg Psychiatry. 1992 Feb;55(2):92–94. [PMC free article] [PubMed]
  • Bullock R, Patterson J, Park C. Evaluation of 99mTc-hexamethylpropyleneamine oxime cerebral blood flow mapping after acute focal ischemia in rats. Stroke. 1991 Oct;22(10):1284–1290. [PubMed]
  • Teasdale G, Jennett B. Assessment of coma and impaired consciousness. A practical scale. Lancet. 1974 Jul 13;2(7872):81–84. [PubMed]
  • Jennett B, Snoek J, Bond MR, Brooks N. Disability after severe head injury: observations on the use of the Glasgow Outcome Scale. J Neurol Neurosurg Psychiatry. 1981 Apr;44(4):285–293. [PMC free article] [PubMed]
  • Oder W, Goldenberg G, Spatt J, Podreka I, Binder H, Deecke L. Behavioural and psychosocial sequelae of severe closed head injury and regional cerebral blood flow: a SPECT study. J Neurol Neurosurg Psychiatry. 1992 Jun;55(6):475–480. [PMC free article] [PubMed]
  • Goldenberg G, Oder W, Spatt J, Podreka I. Cerebral correlates of disturbed executive function and memory in survivors of severe closed head injury: a SPECT study. J Neurol Neurosurg Psychiatry. 1992 May;55(5):362–368. [PMC free article] [PubMed]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group