PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of jnnpsycJournal of Neurology, Neurosurgery and PsychiatryVisit this articleSubmit a manuscriptReceive email alertsContact usBMJ
 
J Neurol Neurosurg Psychiatry. 1995 November; 59(5): 516–519.
PMCID: PMC1073715

Spontaneous intracranial hypotension from a CSF leak in a patient with Marfan's syndrome.

Abstract

A patient with Marfan's syndrome had spontaneous intracranial hypotension secondary to a proved CSF leak. It is postulated that the leak was caused by minor, unrecognised trauma rupturing spinal arachnoid diverticula. The diverticula were probably pre-existing abnormalities complicating the Marfan's syndrome. It is concluded that patients with spinal meningeal defects may be at increased risk of developing CSF leaks, possibly secondary to unrecognised trauma.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.0M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Images in this article

Click on the image to see a larger version.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Labadie EL, van Antwerp J, Bamford CR. Abnormal lumbar isotope cisternography in an unusual case of spontaneous hypoliquorrheic headache. Neurology. 1976 Feb;26(2):135–139. [PubMed]
  • Marcelis J, Silberstein SD. Spontaneous low cerebrospinal fluid pressure headache. Headache. 1990 Mar;30(4):192–196. [PubMed]
  • Hochman MS, Naidich TP, Kobetz SA, Fernandez-Maitin A. Spontaneous intracranial hypotension with pachymeningeal enhancement on MRI. Neurology. 1992 Aug;42(8):1628–1630. [PubMed]
  • Sable SG, Ramadan NM. Meningeal enhancement and low CSF pressure headache. An MRI study. Cephalalgia. 1991 Dec;11(6):275–276. [PubMed]
  • Fishman RA, Dillon WP. Dural enhancement and cerebral displacement secondary to intracranial hypotension. Neurology. 1993 Mar;43(3 Pt 1):609–611. [PubMed]
  • Rando TA, Fishman RA. Spontaneous intracranial hypotension: report of two cases and review of the literature. Neurology. 1992 Mar;42(3 Pt 1):481–487. [PubMed]
  • Beighton P, de Paepe A, Danks D, Finidori G, Gedde-Dahl T, Goodman R, Hall JG, Hollister DW, Horton W, McKusick VA, et al. International Nosology of Heritable Disorders of Connective Tissue, Berlin, 1986. Am J Med Genet. 1988 Mar;29(3):581–594. [PubMed]
  • Tsipouras P, Del Mastro R, Sarfarazi M, Lee B, Vitale E, Child AH, Godfrey M, Devereux RB, Hewett D, Steinmann B, et al. Genetic linkage of the Marfan syndrome, ectopia lentis, and congenital contractural arachnodactyly to the fibrillin genes on chromosomes 15 and 5. The International Marfan Syndrome Collaborative Study. N Engl J Med. 1992 Apr 2;326(14):905–909. [PubMed]
  • Pyeritz RE, Fishman EK, Bernhardt BA, Siegelman SS. Dural ectasia is a common feature of the Marfan syndrome. Am J Hum Genet. 1988 Nov;43(5):726–732. [PubMed]
  • Raftopoulos C, Pierard GE, Rétif C, Braude P, Brotchi J. Endoscopic cure of a giant sacral meningocele associated with Marfan's syndrome: case report. Neurosurgery. 1992 May;30(5):765–768. [PubMed]
  • Smith MD. Large sacral dural defect in Marfan syndrome. A case report. J Bone Joint Surg Am. 1993 Jul;75(7):1067–1070. [PubMed]
  • Strand RD, Eisenberg HM. Anterior sacral meningocele in association with Marfan's syndrome. Radiology. 1971 Jun;99(3):653–654. [PubMed]
  • Weir B. Leptomeningeal cysts in congenital ectopia lentis. Case report. J Neurosurg. 1973 May;38(5):650–654. [PubMed]
  • Barter JF, Addison WA, Rosenberg ER, Hammond CB. Anterior sacral meningocele presenting as a pelvic mass and diagnosed only at celiotomy after an extensive workup. A case report. J Reprod Med. 1983 Oct;28(10):684–686. [PubMed]
  • Fishman EK, Zinreich SJ, Kumar AJ, Rosenbaum AE, Siegelman SS. Sacral abnormalities in Marfan syndrome. J Comput Assist Tomogr. 1983 Oct;7(5):851–856. [PubMed]
  • Robinson L, Dominguez R, Cabrera J, Yeakley JW, Fenstermacher MJ, Milner ME. Multiple meningeal cysts in Marfan syndrome. AJNR Am J Neuroradiol. 1989 Nov-Dec;10(6):1275–1276. [PubMed]
  • Cilluffo JM, Gomez MR, Reese DF, Onofrio BM, Miller RH. Idiopathic ("congenital") spinal arachnoid diverticula. Clinical diagnosis and surgical results. Mayo Clin Proc. 1981 Feb;56(2):93–101. [PubMed]
  • Harkens KL, el-Khoury GY. Intrasacral meningocele in a patient with Marfan syndrome. Case report. Spine (Phila Pa 1976) 1990 Jun;15(6):610–612. [PubMed]
  • Lake PA, Minckler J, Scanlan RL. Spinal epidural cyst: theories of pathogenesis. Case report. J Neurosurg. 1974 Jun;40(6):774–778. [PubMed]
  • NOSIK WA. Intracranial hypotension secondary to lumbar nerve sleeve tear. J Am Med Assoc. 1955 Mar 26;157(13):1110–1111. [PubMed]
  • BELL WE, JOYNT RJ, SAHS AL. Low spinal fluid pressure syndromes. Neurology. 1960 May;10:512–521. [PubMed]
  • Stern WE. Dural ectasia and the Marfan syndrome. J Neurosurg. 1988 Aug;69(2):221–227. [PubMed]
  • Gibson BE, Wedel DJ, Faust RJ, Petersen RC. Continuous epidural saline infusion for the treatment of low CSF pressure headache. Anesthesiology. 1988 May;68(5):789–791. [PubMed]
  • Szeinfeld M, Ihmeidan IH, Moser MM, Machado R, Klose KJ, Serafini AN. Epidural blood patch: evaluation of the volume and spread of blood injected into the epidural space. Anesthesiology. 1986 Jun;64(6):820–822. [PubMed]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group