PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of jnnpsycJournal of Neurology, Neurosurgery and PsychiatryVisit this articleSubmit a manuscriptReceive email alertsContact usBMJ
 
J Neurol Neurosurg Psychiatry. 1995 January; 58(1): 104–106.
PMCID: PMC1073281

Hyperfibrinolysis during intracranial surgery: effect of high dose aprotinin.

Abstract

A patient undergoing intracranial surgery developed disseminated intravascular coagulation with life threatening peroperative bleeding. Thromboelastography established the diagnosis of hyperfibrinolysis, usually a fatal complication of a neurosurgical operation. With the administration of a high dose regimen of aprotinin (Trasylol) the haemorrhage was controlled and the hyperfibrinolytic state reversed. Evaluation of blood samples from the jugular bulb suggested that there was a pronounced local release of tissue plasminogen activator into the circulation.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (404K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Kalter RD, Saul CM, Wetstein L, Soriano C, Reiss RF. Cardiopulmonary bypass. Associated hemostatic abnormalities. J Thorac Cardiovasc Surg. 1979 Mar;77(3):427–435. [PubMed]
  • Kratzer MA, Dieterich J, Denecke H, Knedel M. Hemostatic variables and blood loss during orthotopic human liver transplantation. Transplant Proc. 1991 Jun;23(3):1906–1911. [PubMed]
  • Brozna JP. Cellular regulation of tissue factor. Blood Coagul Fibrinolysis. 1990 Oct;1(4-5):415–426. [PubMed]
  • Kaufman HH, Moake JL, Olson JD, Miner ME, duCret RP, Pruessner JL, Gildenberg PL. Delayed and recurrent intracranial hematomas related to disseminated intravascular clotting and fibrinolysis in head injury. Neurosurgery. 1980 Nov;7(5):445–449. [PubMed]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Group