PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of jepicomhJournal of Epidemiology and Community HealthVisit this articleSubmit a manuscriptReceive email alertsContact usBMJ
 
J Epidemiol Community Health. 1993 August; 47(4): 287–289.
PMCID: PMC1059794

Ovarian cancer and ABO blood groups.

Abstract

OBJECTIVE--To determine whether the distribution of ABO blood groups in women with ovarian cancer differs from that in the general population in a large, defined English region. DESIGN--Analysis of record abstracts of hospital care held in the Oxford record linkage study supplemented with data from the Oxford cancer registry. SETTING--Oxford Regional Health Authority area. SUBJECTS--A total of 1261 women who had ovarian cancer between 1968 and 1986 with ABO blood groups recorded on the Oxford Record Linkage Study and cross checked against the cancer registry comprised the study group. MEASUREMENTS AND MAIN RESULTS--The relative incidence of A:O and B:O blood groups in women with ovarian cancer were compared with the general population in the same region. Ovarian cancer was more common in women of blood group A than in others, with a relative incidence of 1.17. In particular, adenocarcinomas were the most common type of tumour and were associated with blood group A. The association was more striking in married women than in single women probably reflecting differences associated with parity. CONCLUSION--The association between ABO blood groups and ovarian cancer found in this English population is similar in size to that reported from several other populations. Childbearing is known to reduce the risk of ovarian cancer and our findings suggest that the blood group association may be most apparent in married, parous (that is, relatively low risk) women.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (554K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Williams C. Ovarian and cervical cancer. BMJ. 1992 Jun 6;304(6840):1501–1504. [PMC free article] [PubMed]
  • Vessey M, Metcalfe A, Wells C, McPherson K, Westhoff C, Yeates D. Ovarian neoplasms, functional ovarian cysts, and oral contraceptives. Br Med J (Clin Res Ed) 1987 Jun 13;294(6586):1518–1520. [PMC free article] [PubMed]
  • McGowan L, Parent L, Lednar W, Norris HJ. The woman at risk for developing ovarian cancer. Gynecol Oncol. 1979 Jun;7(3):325–344. [PubMed]
  • Ponder BA. Genetic predisposition to cancer. Br J Cancer. 1991 Aug;64(2):203–204. [PubMed]
  • OSBORNE RH, DEGEORGE FV. THE ABO BLOOD GROUPS IN NEOPLASTIC DISEASE OF THE OVARY. Am J Hum Genet. 1963 Dec;15:380–388. [PubMed]
  • Mori M, Kiyosawa H, Miyake H. Case-control study of ovarian cancer in Japan. Cancer. 1984 Jun 15;53(12):2746–2752. [PubMed]
  • Björkholm E. Blood group distribution in women with ovarian cancer. Int J Epidemiol. 1984 Mar;13(1):15–17. [PubMed]
  • Bjarnason O, Tulinius H. Tumours in Iceland. 9. Malignant tumours of the ovary. A histological classification, epidemiological considerations and survival. Acta Pathol Microbiol Immunol Scand A. 1987 Jul;95(4):185–192. [PubMed]

Articles from Journal of Epidemiology and Community Health are provided here courtesy of BMJ Publishing Group