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J Epidemiol Community Health. 1988 March; 42(1): 30–37.
PMCID: PMC1052677

Lactation and cancer risk: is there a relation specific to breast cancer?


Relations between previous lactation experience and risks of cancer of the breast and other sites were investigated after follow-up of 50,274 parous women from 1961 through 1980. Among women with complete information on lactation, 5102 developed cancer and, of these, 1136 were diagnosed with breast cancer. Analyses of associations with mean duration of lactation per birth and duration for each of the three first births suggested a nonlinear relation to breast cancer. The highest risk was observed for those with intermediate duration of breast feeding, whereas lower risks were found among those with very short or very long duration. For all nongenital cancers combined, decreased risks were observed among those with the longest duration of breast feeding. However, among cancers of specific sites, a significant inverse association was found for pancreatic cancer only. The overall impression given by our data is that breast feeding is not strongly related to risks of breast cancer or any other common cancer.

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Selected References

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  • Byers T, Graham S, Rzepka T, Marshall J. Lactation and breast cancer. Evidence for a negative association in premenopausal women. Am J Epidemiol. 1985 May;121(5):664–674. [PubMed]
  • McTiernan A, Thomas DB. Evidence for a protective effect of lactation on risk of breast cancer in young women. Results from a case-control study. Am J Epidemiol. 1986 Sep;124(3):353–358. [PubMed]
  • Kvåle G, Heuch I, Eide GE. A prospective study of reproductive factors and breast cancer. I. Parity. Am J Epidemiol. 1987 Nov;126(5):831–841. [PubMed]
  • Kvåle G, Heuch I. A prospective study of reproductive factors and breast cancer. II. Age at first and last birth. Am J Epidemiol. 1987 Nov;126(5):842–850. [PubMed]
  • PEDERSEN E. [Mass examinations with special reference to breast cancer. An attempt at evaluation]. Tidsskr Nor Laegeforen. 1962 Aug 15;82:1042–1051. [PubMed]
  • Thomas DG, Gart JJ. Stratified trend and homogeneity analyses of proportions and life table data. Comput Biomed Res. 1983 Apr;16(2):116–126. [PubMed]
  • Anderson JD. Breast feeding and breast cancer. S Afr Med J. 1975 Mar 22;49(13):479–482. [PubMed]
  • Ing R, Petrakis NL, Ho JH. Unilateral breast-feeding and breast cancer. Lancet. 1977 Jul 16;2(8029):124–127. [PubMed]
  • LILIENFELD AM. THE EPIDEMIOLOGY OF BREAST CANCER. Cancer Res. 1963 Oct;23:1503–1513. [PubMed]
  • MacMahon B, Lin TM, Lowe CR, Mirra AP, Ravnihar B, Salber EJ, Trichopoulos D, Valaoras VG, Yuasa S. Lactation and cancer of the breast. A summary of an international study. Bull World Health Organ. 1970;42(2):185–194. [PubMed]
  • Wynder EL, Escher GC, Mantel N. An epidemiological investigation of cancer of the endometrium. Cancer. 1966 Apr;19(4):489–520. [PubMed]
  • Elwood JM, Cole P, Rothman KJ, Kaplan SD. Epidemiology of endometrial cancer. J Natl Cancer Inst. 1977 Oct;59(4):1055–1060. [PubMed]
  • Kelsey JL, LiVolsi VA, Holford TR, Fischer DB, Mostow ED, Schwartz PE, O'Connor T, White C. A case-control study of cancer of the endometrium. Am J Epidemiol. 1982 Aug;116(2):333–342. [PubMed]
  • Risch HA, Weiss NS, Lyon JL, Daling JR, Liff JM. Events of reproductive life and the incidence of epithelial ovarian cancer. Am J Epidemiol. 1983 Feb;117(2):128–139. [PubMed]
  • West RO. Epidemiologic study of malignancies of the ovaries. Cancer. 1966 Jul;19(7):1001–1007. [PubMed]
  • Wynder EL, Dodo H, Barber HR. Epidemiology of cancer of the ovary. Cancer. 1969 Feb;23(2):352–370. [PubMed]
  • Hildreth NG, Kelsey JL, LiVolsi VA, Fischer DB, Holford TR, Mostow ED, Schwartz PE, White C. An epidemiologic study of epithelial carcinoma of the ovary. Am J Epidemiol. 1981 Sep;114(3):398–405. [PubMed]
  • Heuch I, Kvåle G, Jacobsen BK, Bjelke E. Use of alcohol, tobacco and coffee, and risk of pancreatic cancer. Br J Cancer. 1983 Nov;48(5):637–643. [PubMed]
  • Johansson ED. The sterile menstrual cycle. The driving force behind pathology in the reproductive organs. Acta Obstet Gynecol Scand Suppl. 1984;123:147–150. [PubMed]

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