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Logo of jmedgeneJournal of Medical GeneticsCurrent TOCInstructions for authors
J Med Genet. Nov 1987; 24(11): 692–695.
PMCID: PMC1050348
Fetal valproate syndrome: is there a recognisable phenotype?
R M Winter, D Donnai, J Burn, and S M Tucker
Kennedy Galton Centre for Clinical Genetics, Radlett, Hertfordshire.
Four infants who were exposed to sodium valproate or valproic acid during pregnancy are described. Common facial features in the three surviving infants include epicanthic folds, a flat nasal bridge, a broad nasal base, anteverted nostrils, a shallow philtrum, and a thin upper lip with a thick lower lip. Ridging of the metopic suture, congenital heart defect, postaxial polydactyly, and hypospadias were additional features in individual cases. In agreement with previous authors, we feel that there is a distinctive 'fetal valproate' phenotype.
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